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Series GSE37576 Query DataSets for GSE37576
Status Public on Jan 01, 2016
Title Gene expression profile of the V/SVZ and the CP at E16
Organism Mus musculus
Experiment type Expression profiling by array
Summary Cell differentiation and proliferation are mutually exclusive. Although differentiating neurons are recognized as post-mitotic non-dividing cells, some Rb- and Rb family (Rb, p107, and p130)-deficient differentiating neurons proliferate and form tumor. Here, we found that the acute inactivation of all Rb family in differentiating cortical excitatory neurons caused radial migration defect and S-phase progression but not cell division, whereas that in cortical progenitors caused the cell division of the differentiating neurons generated from Rb –/–; p107 –/–; p130 –/– (Rb-TKO) progenitors. Genome-wide DNA methylation analysis revealed that proximal promoters tended to become methylated during differentiation in vivo. DNA demethylation by DNA methyltransferase inhibitor allowed the acutely inactivated Rb-TKO differentiating neurons to undergo G2/M-phase progression. Our finding illustrate that cortical excitatory neurons epigenetically lose their proliferative potency after neurogenesis.
Overall design 4 samples of the V/SVZ (ventricular/subventricular zone) tissue and 4 samples of the CP (cortical plate) tissue
Contributor(s) Ajioka I, Oshikawa M
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Submission date Apr 25, 2012
Last update date Nov 01, 2017
Contact name Itsuki Ajioka
Organization name Tokyo Medical and Dental University
Department Center for Brain Integration Research
Street address 1-5-45 Yushima, Bunkyo-ku
City Tokyo
ZIP/Postal code 113-8510
Country Japan
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (8)
GSM922307 V/SVZ_1
GSM922308 V/SVZ_2
GSM922309 V/SVZ_3
This SubSeries is part of SuperSeries:
GSE37625 V/SVZ (ventricular/subventricular zone) tissue and CP (cortical plate) tissue at E16
BioProject PRJNA161879

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37576_RAW.tar 17.3 Mb (http)(custom) TAR (of TXT)
GSE37576_matrix_filtered_CP-VZ.txt.gz 712.5 Kb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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