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Series GSE37469 Query DataSets for GSE37469
Status Public on Feb 13, 2013
Title Minor clone provides a reservoir for relapse in multiple myeloma
Organism Homo sapiens
Experiment type Expression profiling by array
Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary In this study we addressed subclonal evolutionary process after treatment and subsequent relapse in multiple myeloma (MM) in a cohort of 24 MM patients treated either with conventional chemotherapy or with the proteasome inhibitor, bortezomib. Because MM is a highly heterogeneous disease coupled with a large number of DNA copy number alterations (CNAs) and loss of heterozygosity (LOH), we focused our study on the secondary genetic events: 1q21 gain, NF-kB activating mutations, RB1 and TP53 deletions, that seem to reflect progression. By using genome-wide high resolution SNP arrays we identified subclones with nonlinear complex evolutionary histories in a third of patients with myeloma, the relapse clone apparently derived from a minor subclone at diagnosis. Such reordering of the spectrum of genetic lesions during therapy is likely to reflect selection of genetically distinct subclones not initially competitive against the dominant population that survived chemotherapy, thrived and acquired new anomalies. In addition we found that emergence of minor subclones at relapse was significantly associated with bortezomib treatment. Altogether, these data support the idea of new strategy of future clinical trials in MM that would combine targeted therapy and subpopulations control to eradicate all myeloma subclones in order to obtain long-term remission.

This SuperSeries is composed of the SubSeries listed below.
Overall design Refer to individual Series
Contributor(s) Magrangeas F, Lodé L, Avet-Loiseau H, Decaux O, Gouraud W, Anderson KC, Moreau P, Munshi NC, Minvielle S
Citation(s) 22874878
Submission date Apr 20, 2012
Last update date Feb 18, 2019
Contact name Wilfried Gouraud
Organization name ICO - UMGC
Department Integrated Center of Oncology René Gauducheau
Lab Omics Data Science Unit
Street address bd Jacques Monod
City Saint Herblain
ZIP/Postal code 44805
Country France
Platforms (4)
GPL3718 [Mapping250K_Nsp] Affymetrix Mapping 250K Nsp SNP Array
GPL3720 [Mapping250K_Sty] Affymetrix Mapping 250K Sty2 SNP Array
GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
Samples (99)
GSM621360 MM_#03
GSM621361 MM_#03R
GSM621362 MM_#03R_blood
This SuperSeries is composed of the following SubSeries:
GSE25262 Genetic adaptability of cancer cells under treatment selection pressure in multiple myeloma patients.
GSE37414 Expression of genetic adaptability of cancer cells under treatment selection pressure in multiple myeloma patients
BioProject PRJNA160167

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37469_RAW.tar 2.7 Gb (http)(custom) TAR (of CEL)

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