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Series GSE37385 Query DataSets for GSE37385
Status Public on Jul 27, 2012
Title Subgroup specific somatic copy number aberrations in the medulloblastoma genome
Organism Homo sapiens
Experiment type Expression profiling by array
Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary Medulloblastoma, the most common malignant pediatric brain tumour is currently treated with non-specific cytotoxic therapies including surgery, whole brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, prior attempts to identify targets for therapy have been underpowered due to small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1087 unique medulloblastomas. SCNAs are more common than SNVs in medulloblastoma, and are predominantly subgroup enriched. The most common region of focal copy number gain is a tandem duplication of the Parkinson's disease gene SNCAIP, which is exquisitely restricted to Subgroup 4alpha. Recurrent translocations of PVT1, including PVT1-MYC and PVT1-NDRG1 that arise through localized chromosomal shattering (topochromothripsis) are restricted to Group 3 tumours. Numerous actionable SCNAs, including recurrent events targeting TGFbeta signaling in Group 3, and NF-kappaB signaling in Group 4 suggest future avenues for rational, targeted therapy

This SuperSeries is composed of the SubSeries listed below.
Overall design Refer to individual Series
Citation(s) 22832581
Submission date Apr 18, 2012
Last update date Jan 08, 2019
Contact name Paul A. Northcott
Organization name German Cancer Research Center (DKFZ)
Street address Im Neuenheimer Feld 280
ZIP/Postal code 69120
Country Germany
Platforms (2)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
GPL11532 [HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version]
Samples (1382)
GSM917011 Primary medulloblastoma sample_MB-7
GSM917012 Primary medulloblastoma sample_MB-14
GSM917013 Primary medulloblastoma sample_MB-16
This SuperSeries is composed of the following SubSeries:
GSE37382 Subgroup specific somatic copy number aberrations in the medulloblastoma genome [mRNA]
GSE37384 Subgroup specific somatic copy number aberrations in the medulloblastoma genome [gDNA]
BioProject PRJNA161029

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37385_RAW.tar 47.1 Gb (http)(custom) TAR (of CEL, CHP)

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