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Series GSE37379 Query DataSets for GSE37379
Status Public on Apr 22, 2013
Title Transcriptome analysis of the livers from mice that had been fed water-soluble extract of Pacific Krill
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Background: We previously reported that intake of a water-soluble extract of Pacific Krill (WEPAK) by mice decreases triglyceride accumulation in liver and suppresses weight gain induced by a high-fat diet. However, the mechanisms mediating these phenomena were not investigated or revealed in our previous study.

Methods and Findings: Here, we investigated the effect of WEPAK in mouse liver using transcriptome analysis and discovered that WEPAK induced the expression of genes categorized into the gene ontology (GO) term lipid metabolic process. Furthermore, two regulators of fatty acid β-oxidation, AMPK and PPARδ, were induced in the liver and muscle of mice that had taken in WEPAK.

Conclusions: These results indicate that WEPAK increased the expression of genes related to fatty acid β-oxidation via activation of AMPK and PPARδ. WEPAK may have the effect of improving lipid metabolism and, therefore, may be beneficial in the prevention of obesity.
Overall design Examination of 4 different feeding condtion (4mice/group)
Contributor(s) Yamada H
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Submission date Apr 18, 2012
Last update date May 15, 2019
Contact name Hidetoshi Yamada
Organization name Iwate Biotechnology Reserch Center
Street address Narita 22-174-4
City Kitakami-shi
State/province Iwate
ZIP/Postal code 024-0003
Country Japan
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (16)
GSM916985 No.4 Liver_SAGE
GSM916986 No.5 Liver_SAGE
GSM916987 No.7 Liver_SAGE
BioProject PRJNA159707
SRA SRP012297

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Supplementary file Size Download File type/resource
GSE37379_table_S2_processed.txt.gz 749.8 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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