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Series GSE36697 Query DataSets for GSE36697
Status Public on Sep 10, 2012
Title Effect of deletion of the selenium-binding protein 1 gene on gene expression in the ovary of C57BL/6J mouse
Organism Mus musculus
Experiment type Expression profiling by array
Summary Selenium-binding protein 1 (SeBP1) is a cytosolic protein expressed in various tissues such as liver, kidney and gonad. This protein is suggested to serve in tumor suppression, anti-aging, modification of oxidative stress, protein transport/degradation in cells, and other phenomena. However, the physiological function of SeBP1 remains obscure because of lack of definitive evidence. To address this issue, we compared gene expression between wild-type and SeBP1-knockout (KO) mice using DNA microarray analysis. The results obtained in this study revealed that the deletion of SeBP1 causes a lot of changes in the expression of proliferation-related genes, including a decrease in myelocytomatosis oncogene and an increase in adenomatosis polyposis coli and tumor necrosis factor. Thus, it is suggested that SeBP1 plays a role in the proliferative and/or anti-proliferative effect via the regulation of these genes.
 
Overall design Total RNAs were extracted from the ovaries of wild-type and SeBP1 KO mice at 20 weeks old (each N=3), and their cDNAs were applied to the analysis using Agilent-026655 Whole Mouse Genome Oligo DNA Microarray (4x44K) version 2.
 
Contributor(s) Tsujimoto S, Takeda T, Yamada H
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Submission date Mar 21, 2012
Last update date Nov 01, 2017
Contact name Tomoki Takeda
E-mail(s) takeda@phar.kyushu-u.ac.jp
Phone +81-92-642-6587
Fax +81-92-642-6588
Organization name Kyushu University
Department Pharmaceutical sciences
Lab Molecular life sciences
Street address 3-1-1 Maidashi, Higashi-ku
City Fukuoka
ZIP/Postal code 812-8582
Country Japan
 
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (6)
GSM898994 W2
GSM898995 W3
GSM898996 W5
Relations
BioProject PRJNA153621

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE36697_RAW.tar 54.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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