|
| Status |
Public on Feb 25, 2012 |
| Title |
Impaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal |
| Organisms |
Caenorhabditis elegans; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Transcriptome profiling of three models with impaired insulin/IGF1 signaling. 1. Deep sequencing of endogenous mRNA from Caenorhabditis elegans N2 var. Bristol (wildtype) and daf-2(e1370) mutant; 2. Deep sequencing of endogenous mRNA from murine embryonic fibroblasts (MEF) wildtype and irs1-/- knockout; 3. Deep sequencing of endogenous mRNA from murine embryoinic fibroblast (MEF) insr+/- -lox and insr+/- knockout
Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
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| |
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| Overall design |
14 samples examined: C. elegans N2 var. Bristol (wildtype) vs. daf-2(e1370) mutant; MEF wildtype vs. irs1-/- knockout; MEF insr+/- -lox vs. insr +/- knockout
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| |
|
| Contributor(s) |
Zarse K, Ristow M, Groth M, Priebe S |
| Citation(s) |
22482728 |
| Submission date |
Feb 23, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
JenAge Project |
| E-mail(s) |
geo-data@jenage.de
|
| Organization name |
Leibniz Institute for Age Research - Fritz Lipmann Institute
|
| Street address |
Beutenbergstr. 11
|
| City |
Jena |
| ZIP/Postal code |
D-07745 |
| Country |
Germany |
| |
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| Platforms (2) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
| GPL13776 |
Illumina Genome Analyzer IIx (Caenorhabditis elegans) |
|
| Samples (14)
|
| GSM879792 |
Endogenous mRNA from N2 var. Bristol (wildtype) 1 |
| GSM879793 |
Endogenous mRNA from daf-2(e1370) mutant 1 |
| GSM879794 |
Endogenous mRNA from N2 var. Bristol (wildtype) 2 |
| GSM879795 |
Endogenous mRNA from daf-2(e1370) mutant 2 |
| GSM879796 |
Endogenous mRNA from N2 var. Bristol (wildtype) 3 |
| GSM879797 |
Endogenous mRNA from daf-2(e1370) mutant 3 |
| GSM879798 |
Endogenous mRNA from MEF wildtype cells 1 |
| GSM879799 |
Endogenous mRNA from MEF irs1-/- knockout cells 1 |
| GSM879800 |
Endogenous mRNA from MEF wildtype cells 2 |
| GSM879801 |
Endogenous mRNA from MEF irs1-/- knockout cells 2 |
| GSM879802 |
Endogenous mRNA from MEF insr+/- -lox cells 1 |
| GSM879803 |
Endogenous mRNA from MEF insr+/- knockout cells 1 |
| GSM879804 |
Endogenous mRNA from MEF insr+/- -lox cells 2 |
| GSM879805 |
Endogenous mRNA from MEF insr+/- knockout cells 2 |
|
| Relations |
| SRA |
SRP011038 |
| BioProject |
PRJNA151765 |
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