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Status |
Public on May 01, 2013 |
Title |
Combined miRNA and mRNA Sequencing Identifies Protective Transcriptional Signature of Enhanced PI3Kalpha Signaling in Cardiac Hypertrophy |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing
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Summary |
A molecular and bioinformatic pipeline permitting comprehensive analysis and quantification of myocardial miRNA and mRNA expression with next-generation sequencing was developed and the impact of enhanced PI3Kalpha signaling on the myocardial transcriptome signature of pressure overload-induced pathological hypertrophy was explored.
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Overall design |
miRNA and mRNA-Seq were carried out in four groups of mouse LV samples: WT sham, WT+TAC, caPI3Kalpha sham, caPI3Kalpha+TAC
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Contributor(s) |
Yang K, Nerbonne J |
Citation(s) |
22580345 |
Submission date |
Jan 25, 2012 |
Last update date |
May 15, 2019 |
Contact name |
Kai-Chien Yang |
Organization name |
Washington University in St Louis
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Department |
Developmental Biology
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Lab |
Nerbonne
|
Street address |
660 South Euclid Avenue Box 8103
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City |
St Louis |
State/province |
MO |
ZIP/Postal code |
63110-1093 |
Country |
USA |
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Platforms (1) |
GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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Samples (27)
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Relations |
SRA |
SRP010588 |
BioProject |
PRJNA152727 |