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Series GSE35350 Query DataSets for GSE35350
Status Public on May 01, 2013
Title Combined miRNA and mRNA Sequencing Identifies Protective Transcriptional Signature of Enhanced PI3Kalpha Signaling in Cardiac Hypertrophy
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary A molecular and bioinformatic pipeline permitting comprehensive analysis and quantification of myocardial miRNA and mRNA expression with next-generation sequencing was developed and the impact of enhanced PI3Kalpha signaling on the myocardial transcriptome signature of pressure overload-induced pathological hypertrophy was explored.
Overall design miRNA and mRNA-Seq were carried out in four groups of mouse LV samples: WT sham, WT+TAC, caPI3Kalpha sham, caPI3Kalpha+TAC
Contributor(s) Yang K, Nerbonne J
Citation(s) 22580345
Submission date Jan 25, 2012
Last update date May 15, 2019
Contact name Kai-Chien Yang
Organization name Washington University in St Louis
Department Developmental Biology
Lab Nerbonne
Street address 660 South Euclid Avenue Box 8103
City St Louis
State/province MO
ZIP/Postal code 63110-1093
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (27)
GSM866644 WT Sham 6 LV miRNA Seq
GSM866645 WT Sham 7 LV miRNA Seq
GSM866646 WT Sham 13 LV miRNA Seq
SRA SRP010588
BioProject PRJNA152727

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Supplementary file Size Download File type/resource
GSE35350_mRNASeq.txt.gz 184.7 Kb (ftp)(http) TXT
GSE35350_miRNASeq.txt.gz 10.9 Kb (ftp)(http) TXT
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