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Series GSE35134 Query DataSets for GSE35134
Status Public on Aug 01, 2013
Title 5/6 nephrectomy (5/6Nx) effect on the brain
Organism Mus musculus
Experiment type Expression profiling by array
Summary Chronic kidney disease (CKD) is a very important problem in global health treatment. CKD increases the disease risk of apoplexy, cardiac failure and cardiac infarction. In addition, neurological complications, including depression and restless legs syndrome, occur in almost all CKD patients; however, the mechanisms of these neurological complications remain unclear. Here, we showed the disruptive effect of chronic renal failure in 5/6 nephrectomy mice on an immobility time of forced swim and tail suspension test and the 24-hr rhythm of Drd2 and clock gene expressions in the striatum. These disruptive effects were induced by abnormal signal transduction in high TGF-β1 expression from the kidney. Abnormal TGF-β signal in the striatum led to TCF7L2 expression and ID2 induced by TCF7L2 led to disruption of the 24-hr rhythm of clock gene expression. These findings suggest that neurological complications in CKD might be overcome by amelioration of the TGF-β signal.
Overall design Differential gene expression between 5/6 nephrectomized and sham-operated mouse was measured on the brain.
Contributor(s) Matsunaga N, Ohdo S, Yasuda K, Doi A, Koyanagi S, Ikeda E, Hamamura K, Hideaki K, Aramaki H
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Submission date Jan 17, 2012
Last update date Nov 01, 2017
Contact name naoya matsunaga
Organization name kyushu university
Street address maidashi 3-1-1, higashi-ku
City fukuoka
ZIP/Postal code 8128582
Country Japan
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (2)
GSM862437 Sham brain
GSM862438 Ope brain
This SubSeries is part of SuperSeries:
GSE35136 5/6 nephrectomy (5/6Nx) effect on the brain and liver
BioProject PRJNA155991

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE35134_RAW.tar 17.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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