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Series GSE33991 Query DataSets for GSE33991
Status Public on Nov 30, 2011
Title Early responding dendritic cells direct local natural killer response to control HSV-1 infection within the cornea
Organism Mus musculus
Experiment type Expression profiling by array
Summary Dendritic cells (DCs) regulate both innate and adaptive immune responses.
The role of CD11c-plus DCs in the corneal response to to herpes simplex virus-1 (HSV-1) infection was investigated by depleting them prior to infection.
 
Overall design Bone marrow cells from CD11c-DTR (C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J) mice were transferred intravenously to irradiated BALB/cJ host mice.
After 6 weeks, the bone marrow chimeric host mice were injected with diphtheria toxin (DT) to deplete CD11c-positive cells.
Two days after injection, the mice were subjected to a standard corneal infection protocol using HSV-1.
 
Contributor(s) Frank GM, Buela K, Maker DM, Harvey SA, Hendricks RL
Citation(s) 22210909
Submission date Nov 29, 2011
Last update date Feb 11, 2019
Contact name Stephen Alan Kenneth Harvey
E-mail(s) stephenaharvey@cs.com
Organization name University of Pittsburgh School of Medicine
Department Ophthalmology
Lab EEINS 1014
Street address 203 Lothrop St
City Pittsburgh
State/province PA
ZIP/Postal code 15213-2588
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (4)
GSM840129 Cornea no DT mock infected
GSM840130 Cornea no DT infected
GSM840131 Cornea plus DT mock infected
Relations
BioProject PRJNA150635

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33991.xls.gz 1.7 Mb (ftp)(http) XLS
GSE33991_RAW.tar 15.8 Mb (http)(custom) TAR (of CEL)
Processed data are available on Series record
Processed data included within Sample table

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