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Status |
Public on Nov 30, 2011 |
Title |
Early responding dendritic cells direct local natural killer response to control HSV-1 infection within the cornea |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Dendritic cells (DCs) regulate both innate and adaptive immune responses. The role of CD11c-plus DCs in the corneal response to to herpes simplex virus-1 (HSV-1) infection was investigated by depleting them prior to infection.
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Overall design |
Bone marrow cells from CD11c-DTR (C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J) mice were transferred intravenously to irradiated BALB/cJ host mice. After 6 weeks, the bone marrow chimeric host mice were injected with diphtheria toxin (DT) to deplete CD11c-positive cells. Two days after injection, the mice were subjected to a standard corneal infection protocol using HSV-1.
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Contributor(s) |
Frank GM, Buela K, Maker DM, Harvey SA, Hendricks RL |
Citation(s) |
22210909 |
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Submission date |
Nov 29, 2011 |
Last update date |
Feb 11, 2019 |
Contact name |
Stephen Alan Kenneth Harvey |
E-mail(s) |
stephenaharvey@cs.com
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Organization name |
University of Pittsburgh School of Medicine
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Department |
Ophthalmology
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Lab |
EEINS 1014
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Street address |
203 Lothrop St
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City |
Pittsburgh |
State/province |
PA |
ZIP/Postal code |
15213-2588 |
Country |
USA |
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Platforms (1) |
GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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Samples (4)
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Relations |
BioProject |
PRJNA150635 |