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Series GSE32870 Query DataSets for GSE32870
Status Public on Aug 31, 2012
Title Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome
Organism Mus musculus
Experiment type Expression profiling by array
Summary To identify the detailed molecular causes of the mitochondrial dysfunction, oxidative burden and more vulnerable redox balance in Rett mouse hippocampus, we screened for differential gene expression in the hippocampal CA1 subfield of adult male mice. A whole mouse genome microarray was performed to assess, whether key enzymes of the mitochondrial respiratory chain or major cellular radical scavenging enzymes are affected in this MeCP2-deficient mouse model of Rett syndrome.
Overall design Comparison of gene expression between male wildtype mice (Mecp2+/y) and mice lacking the MECP2 gene (Mecp2-/y) [B6.129P2(C)-Mecp2tm-1-1Bird (Guy et al. 2001, Nat. Genet. 27: 322-326)]. In total, 9 mice of each genotype were analyzed. The mRNA of groups of 3 animals was pooled to generate 3 independent biological samples, and finally three microarrays were run for each genotype.
Contributor(s) Großer E, Fischer M, Hildebrandt B, Menzfeld C, Vogelgesang S, Manzke TU, Opitz L, Salinas-Riester G, Müller M
Citation(s) 22750529
Submission date Oct 11, 2011
Last update date Jan 19, 2018
Contact name Gabriela Salinas
Organization name Universitaetsmedizin Goettingen
Department Department of Pathology
Lab NGS Integrative Genomics
Street address Kreuzbergring 57
City Goettingen
State/province Lower-Saxony
ZIP/Postal code 37075
Country Germany
Platforms (1)
GPL10333 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version)
Samples (8)
GSM813592 1.0_Sample_25_22_21_WT_1.1
GSM813593 1.1_Sample_19_20_24_WT_1.4
GSM813594 1.3_Sample_10_13_23_WT_2.4
BioProject PRJNA146559

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32870_RAW.tar 23.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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