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Series GSE32530 Query DataSets for GSE32530
Status Public on Oct 23, 2011
Title Primary tumor grafts as advanced models for breast cancer that authentically reflect tumor histopathology, growth, metastasis, and patient outcomes (copy number)
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
Summary Development and pre-clinical testing of new cancer therapies is limited by the scarcity of in vivo models that authentically
reproduce tumor growth and metastatic progression. We report new models for breast tumor growth and metastasis, in the form
of transplantable tumors derived directly from individuals undergoing treatment for breast cancer. These tumor grafts represent
the diversity of human breast cancer and maintain essential features of the original tumors, including metastasis to specific
sites. Co-engraftment of primary human mesenchymal stem cells maintains phenotypic stability of the grafts and increases tumor
growth by promoting angiogenesis. We also report that tumor engraftment is a prognostic indicator of disease outcome for newly
diagnosed women; orthotopic breast tumor grafting marks a step toward individualized models for tumor growth, metastasis,
and prognosis. This bank of tumor grafts also serves as a publicly available resource for new models in which to study the biology of
breast cancer.
Overall design Single replicates of genomic DNA from 12 human breast cancer tumors and xenografts of those tumors in immunodeficient mice were hybridized to Affymetrix Human SNP 6.0 genotyping arrays.
Contributor(s) DeRose YS, Wang G, Lin Y, Bernard PS, Buys SS, Ebbert MT, Factor R, Matsen C, Milash BA, Nelson E, Neumayer L, Randall L, Stijleman IJ, Welm BE, Welm AL
Citation(s) 22019887
Submission date Sep 30, 2011
Last update date Nov 27, 2018
Contact name Alana Welm
Phone 801-587-4622
Organization name Huntsman Cancer Institute / University of Utah
Department Oncological Sciences
Street address 2000 Circle of Hope
City Salt Lake City
State/province UT
ZIP/Postal code 84112
Country USA
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (24)
GSM805868 HCI-001 original tumor [copy number]
GSM805869 HCI-001 xenograft 2nd passage [copy number]
GSM805870 HCI-001 xenograft 5th passage [copy number]
This SubSeries is part of SuperSeries:
GSE32532 Patient-derived tumor grafts authentically reflect tumor pathology, growth, metastasis, and disease outcomes
BioProject PRJNA154437

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32530_RAW.tar 764.2 Mb (http)(custom) TAR (of CEL)
GSE32530_copynumber_table.txt.gz 148.6 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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