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Series GSE32395 Query DataSets for GSE32395
Status Public on Nov 30, 2011
Title miRNA profiling in osteosarcoma: a cell line based approach with correlation to gene expression
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We found various genes involved in differentiation (RGMB, LRRC17), cell cycle control (Cyclin E1) and apoptosis (LIMA1, CAMK2N1) were found to be deregulated in osteosarcoma cell lines, most likely due to altered miRNA expression patterns.
Our findings indicate a crucial impact of deregulated miRNAs with consecutive changes in gene expression in osteosarcomas that strongly suggests pathogenetic and potentially therapeutic implications.
Overall design We investigated seven well-established osteosarcoma cell lines for genome wide miRNA expression (miRBase version 15.0) and integrated our findings with gene expression
This represents the mRNA component of the study
Contributor(s) Baumhoer D, Zillmer S, Unger K, Rosemann M, Atkinson MJ, Irmler M, Beckers J, Siggelkow H, von Luettichau I, Jundt G, Smida J, Nathrath M
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Submission date Sep 26, 2011
Last update date Jul 26, 2018
Contact name Jan Smida
Phone 00498937813797
Fax 00498931873381
Organization name HelmholtzZentrum
Department CCg Osteosarcoma
Lab 57/129
Street address Ingolstaedter Land 1
City Neuherberg
ZIP/Postal code D-85764
Country Germany
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (9)
GSM801862 HOS osteosarcoma cell line CRL-1543
GSM801863 HOS-58 osteosarcoma cell line
GSM801864 U2-OS osteosarcoma cell line HTB-96
BioProject PRJNA147947

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32395_RAW.tar 38.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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