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| Status |
Public on Dec 07, 2011 |
| Title |
Genome-wide analysis of lupus immune complex stimulation of peripheral blood mononuclear cells and how this is regulated by C1q |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The goal of this study was to determine what genes are up- and down-regulated in response to lupus immune complexes in total peripheral blood mononuclear cells (PBMCs). Our results have shown that novel genes are induced by immune complexes that are likely important for lupus pathogenesis plus that C1q regulates these pathways and induces multiple new pathways not previously identified.
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| Overall design |
Total RNA was isolated from PBMCs from 2 donors after 5 hours with the following condiitons: 1) Unstimulated, 2) Lupus immune complex alone, 3) Lupus immune complex + C1q, 4) C1q alone
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| |
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| Contributor(s) |
Santer DM, Basom R, Elkon KB |
| Citation(s) |
22147767 |
| Submission date |
Sep 21, 2011 |
| Last update date |
Mar 20, 2017 |
| Contact name |
Deanna Santer |
| Organization name |
University of Washington
|
| Street address |
1959 NE Pacific St Health Science Bldg BB561 Campus Box 356428
|
| City |
Seattle |
| ZIP/Postal code |
98195 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE32285 |
Genome-wide analysis of lupus immune complex stimulation and how this response is regulated by C1q |
|
| Relations |
| BioProject |
PRJNA154515 |
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