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Series GSE32152 Query DataSets for GSE32152
Status Public on Oct 01, 2011
Title Mammary Tissue: Wild type mammary glands vs IGF-IR induced mammary tumors vs IGF-IR independent tumors
Organism Mus musculus
Experiment type Expression profiling by array
Summary Molecular profiling was used to classify mammary tumors that develop in MTB-IGFIR transgenic mice. It was determined that the primary mammary tumors (PMT), which develop due to elevated expression of the type I insulin-like growth factor receptor (IGF-IR) in mammary epithelial cells, most closely resemble murine tumors with basal-like or mixed gene expression profiles and with human basal-like breast cancers. Downregulation of IGF-IR transgene in MTB-IGFIR tumor-bearing mice leads to the regression of most of the tumors followed by tumor re-appearance in some of the mice. These tumors that re-appear following IGF-IR transgene downregulation do not express the IGF-IR transgene and cluster with murine mammary tumors that express a mesenchymal gene expression profile and with human claudin-low breast cancers. Therefore, IGF-IR overexpression in murine mammary epithelial cells induces mammary tumors with primarily basal-like characteristics while tumors that develop following IGF-IR downregulation express a gene signature that most closely resembles human claudin-low breast tumors.
Overall design Three conditions: 8 wild type (WT) mammary glands, 11 primary mammary tumor (PMT) samples, 9 recurrent spindle tumor (RST) samples, each sample was hybridized against a universal mouse reference RNA
Contributor(s) Moorehead RA, Livingstone J
Citation(s) 22020329, 30597648
Submission date Sep 15, 2011
Last update date Feb 27, 2019
Contact name Roger A Moorehead
Phone 519-824-4120 (54950)
Fax 519-767-1450
Organization name University of Guelph
Department Department of Biomedical Sciences
Street address 50 Stone Rd East
City Guelph
State/province Ontario
ZIP/Postal code N1G2W1
Country Canada
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (28)
GSM796726 PMT_sample1
GSM796727 RST_sample1
GSM796728 WT_sample1
BioProject PRJNA147647

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32152_RAW.tar 401.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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