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Series GSE32079 Query DataSets for GSE32079
Status Public on Jun 11, 2012
Title Mutations in IDH1 and IDH2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary We compared the DNA methylation profiles of 12 intrahepatic cholangiocarcinomas harboring mutations in the genes encoding isocitrate dehydrogenase, IDH1 and IDH2, with 28 intrahepatic cholangiocarcinomas without these mutations.
We profiled these samples with the Illumina HumanMethylation450 BeadChip, and characterized over 2,000 genes that were hypermethylated in tumors with mutations in IDH1 or IDH2.
Overall design Genomic DNA from fresh frozen tumors was bisulfite converted with the Zymo Research EZ DNA Methylation kit, then hybridized to the Illumina HumanMethylation450 Beadchip.
Contributor(s) Wang P, Zhang C, Kuan PF, Kim JW, Yourstone SM, Chiang DY
Citation(s) 22824796
Submission date Sep 13, 2011
Last update date Mar 22, 2019
Contact name Derek Chiang
Organization name University of North Carolina
Department Department of Genetics
Street address UNC Lineberger Cancer Center, 450 West Drive, CB #7295
City Chapel Hill
State/province NC
ZIP/Postal code 27599-7295
Country USA
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (68)
GSM795354 Cholangiocarcinoma A2_4129
GSM795355 Cholangiocarcinoma A6_7258
GSM795356 Cholangiocarcinoma A10_6284
This SubSeries is part of SuperSeries:
GSE32286 DNA hypermethylation in intrahepatic cholangiocarcinomas and glioblastomas
BioProject PRJNA154939

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32079_RAW.tar 183.1 Mb (http)(custom) TAR
GSE32079_non-normalized.txt.gz 222.3 Mb (ftp)(http) TXT
Processed data included within Sample table

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