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Series GSE31272 Query DataSets for GSE31272
Status Public on Sep 15, 2015
Title NF-kB activation confers a prolonged event-free-survival in newly diagnosed myeloma patients harboring t(4;14) treated with bortezomib.
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary NF-kB pathway activation is the hallmark of hematological malignancies.
In multiple myeloma (MM), a large variety of genomic alterations leading to either inactivation of repressor such as TRAF3, CYLD or cIAP1/2 or amplification of activators such as CD40 or NIK collectively contribute to frequently deregulate NF-kB signaling.
In order to evaluate the prognostic impact of NF-kB mutations in MM, we performed a comprehensive analysis of a panel of newly diagnosed patients with cIAP1/2 biallelic deletion. We found that all patients have dysregulated NF-kB pathway and the majority of them presented t(4;14).
Then we analyzed clinical outcome of 37 MM at presentation with t(4;14) and treated with bortezomib according to their NF-kB status. We showed that increase of NF-kB activity confers prolonged event-free survival.
Altogether, our data suggest that NF-kB activation resulting from NF-kB mutations (ie cIAP1/2 deletion) or other mechanisms improves outcome of t(4;14)-positive MM treated with bortezomib.
Overall design NF-kB pathway examined for 34 myeloma patients with high resolution genome-wide chip

SUBMITTER_COMMENT: Relevant clinical data are included in the original paper, please read the article.
Contributor(s) Magrangeas F, Avet-Loiseau H, Campion L, Guérin C, Gouraud W, Moreau P, Munshi NC, Minvielle S
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Submission date Aug 09, 2011
Last update date Nov 27, 2018
Contact name Wilfried Gouraud
Organization name ICO - UMGC
Department Integrated Center of Oncology René Gauducheau
Lab Omics Data Science Unit
Street address bd Jacques Monod
City Saint Herblain
ZIP/Postal code 44805
Country France
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (34)
GSM822329 KMS 28PE
GSM822330 MM_0DQjo
GSM822331 MM_14KBq
BioProject PRJNA146137

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE31272_RAW.tar 1.7 Gb (http)(custom) TAR (of CEL, TXT)
Processed data included within Sample table
Processed data provided as supplementary file

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