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Series GSE31270 Query DataSets for GSE31270
Status Public on Sep 02, 2011
Title Control of Embryonic Stem Cell Lineage Commitment by Core Promoter Factor, TAF3 (ChIP-Seq data)
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We report that TAF3, a TBP-associated core promoter factor, is highly enriched in ES cells. In addition to its role in the core promoter recognition complex TFIID, genome-wide binding studies reveal that TAF3 localizes to chromosomal regions bound by CTCF and cohesin. Enrichment for TAF3/CTCF/cohesin bound regions distinguishes TAF3-activated from TAF3-repressed genes. Our findings support a new role of TAF3 in mediating long-range chromatin regulatory interactions to safeguard the finely-balanced transcriptional programs that give rise to pluripotency.
Overall design Genome-wide binding of TAF3, TAF1, TBP and PolII assayed by ChIP-Seq.
Contributor(s) Scannell DR, Tjian R
Citation(s) 21884934
Submission date Aug 08, 2011
Last update date May 15, 2019
Contact name Devin Scannell
Phone 001-510-666-3640
Organization name UC Berkeley
Department QB3
Lab Eisen
Street address 378 Stanley Hall #3220
City Berkeley
State/province CA
ZIP/Postal code 94720
Country USA
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (7)
GSM774940 TAF3 Treatment IP, ES Cells
GSM774941 TAF3 Mock IP, ES Cells
GSM774942 TAF1 Treatment IP, ES Cells
This SubSeries is part of SuperSeries:
GSE30959 Control of Embryonic Stem Cell Lineage Commitment by Core Promoter Factor, TAF3
SRA SRP007833
BioProject PRJNA154137

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE31270_RAW.tar 17.4 Gb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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