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Series GSE30597 Query DataSets for GSE30597
Status Public on Mar 06, 2012
Title Opposing effects of estrogen and Runx2 on breast cancer cell proliferation: identification of a reciprocally-regulated gene signature with clinical prognostic value.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Analysis of reciprocal modulation of Runx2 and E2 signaling in BCA. Our objective was to investigate whether the interaction between estrogen and Runx2 signaling in breast cancer (BCa) could help refine an estrogen-responsive gene signature with improved prognostic value.
 
Overall design MCF7/Rx2dox BCa cells conditionally expressing Runx2 upon doxycycline treatment were treated with estradiol and/or doxycycline to induce Runx2, and global gene expression was profiled to define genes regulated by estradiol, Runx2, or both.
 
Contributor(s) Chimge N, Frenkel B
Citation(s) 22147940
Submission date Jul 12, 2011
Last update date Mar 20, 2017
Contact name Nyam-Osor Chimge
E-mail(s) chimgee@usc.edu
Phone 323-442-3914
Organization name USC
Department IGM
Street address 2250 Alcazar street
City Los Angeles
State/province CA
ZIP/Postal code 91801
Country USA
 
Platforms (1)
GPL6883 Illumina HumanRef-8 v3.0 expression beadchip
Samples (10)
GSM758987 Dox treatment 48h rep1
GSM758988 Dox treatment 48h rep2
GSM758989 Dox treatment 48h rep3
Relations
BioProject PRJNA144569

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE30597_RAW.tar 3.9 Mb (http)(custom) TAR
GSE30597_non-normalized.txt.gz 1.6 Mb (ftp)(http) TXT
GSE30597_normalized.txt.gz 1.5 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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