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Status |
Public on Mar 06, 2012 |
Title |
Opposing effects of estrogen and Runx2 on breast cancer cell proliferation: identification of a reciprocally-regulated gene signature with clinical prognostic value. |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Analysis of reciprocal modulation of Runx2 and E2 signaling in BCA. Our objective was to investigate whether the interaction between estrogen and Runx2 signaling in breast cancer (BCa) could help refine an estrogen-responsive gene signature with improved prognostic value.
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Overall design |
MCF7/Rx2dox BCa cells conditionally expressing Runx2 upon doxycycline treatment were treated with estradiol and/or doxycycline to induce Runx2, and global gene expression was profiled to define genes regulated by estradiol, Runx2, or both.
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Contributor(s) |
Chimge N, Frenkel B |
Citation(s) |
22147940 |
Submission date |
Jul 12, 2011 |
Last update date |
Mar 20, 2017 |
Contact name |
Nyam-Osor Chimge |
E-mail(s) |
chimgee@usc.edu
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Phone |
323-442-3914
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Organization name |
USC
|
Department |
IGM
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Street address |
2250 Alcazar street
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City |
Los Angeles |
State/province |
CA |
ZIP/Postal code |
91801 |
Country |
USA |
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Platforms (1) |
GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
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Samples (10)
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Relations |
BioProject |
PRJNA144569 |