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Series GSE30338 Query DataSets for GSE30338
Status Public on Feb 16, 2012
Title Methylation analysis of 81 glioma clinical samples (49 CIMP+ and 32 CIMP-) and 53 cell line samples
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Glioma CIMP (G-CIMP) is a powerful determinant of tumor pathogenicity but the molecular cause of G-CIMP is a fundamental question that is unresolved. Here, we show that mutation of a single gene, isocitrate dehydrogenase 1 (IDH1), directly causes the G-CIMP in gliomas by remodeling the methylome.
Overall design In this study 81 glioma clinic samples (49 CIMP+ and 32 CIMP-) were analyzed. Parental IDH1 wild-type and IDH1 mutant cells were passaged until passage 50.
Contributor(s) Fang F, Chan T
Citation(s) 22343889, 27165745
Submission date Jun 30, 2011
Last update date Oct 04, 2019
Contact name FANG FANG
Phone 646-8882783
Fax 646-8882595
Organization name Memorial Sloan-Kettering Cancer Center
Department The Human Oncology and Pathogenesis Program
Lab Timothy Chan
Street address 1275 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (134)
GSM752160 Tumor ID 21
GSM752161 Tumor ID 22
GSM752162 Tumor ID 23
This SubSeries is part of SuperSeries:
GSE30339 IDH1 Mutation is a Master Regulator of Epigenomic Remodeling and is Sufficient to Establish the Glioma Hypermethylator Phenotype
BioProject PRJNA154817

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE30338_53cellline_methylation_intensity.txt.gz 21.2 Mb (ftp)(http) TXT
GSE30338_81clinic_53cellline_rawbeta.txt.gz 243.8 Mb (ftp)(http) TXT
GSE30338_81clinic_methylation_intensity.txt.gz 658.3 Mb (ftp)(http) TXT
GSE30338_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data included within Sample table

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