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Series GSE29746 Query DataSets for GSE29746
Status Public on Oct 25, 2011
Title Transcriptional analysis of normal and pathological synovial fibroblasts
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The aim of this study was to compare gene expression between two pathological groups of human synovial fibroblasts (SF) from rheumatoid arthritis (RA) and osteoarthritis (OA) synovial tissues with normal SF from healthy individuals (HSF). We used microarray expression profiling in SF cultured from OA, RA and normal synovial tissues. We found larger numbers of transcripts with differential expression in OASF compared to the other groups than in RASF compared to HSF. This data demonstrate that cultured OASF display a more robust transcriptomic profile than RASF when compared to HSF.
Overall design Synovial fibroblasts were obtained from 9 patients with rheumatoid arthritis (RASF), 11 sex and age matched adult healthy donors (HSF) and 11 sex and age matched patients with OA (OASF). SF were collected under similar subconfluent conditions 24h after serum addition. 31 microarray data were used for determine the statistical significance (p value) of the differences in gene expression.
Contributor(s) Del Rey MJ, Usategui A, Izquierdo E, Cañete JD, Blanco FJ, Criado G, Pablos JL
Citation(s) 22021863
Submission date Jun 05, 2011
Last update date Feb 22, 2018
Contact name Manuel J Del Rey
Phone 0034 91 3908766
Organization name Instituto de Investigación Hospital 12 de Octubre
Department Grupo de Enfermedades Inflamatorias y Autoinmunes
Street address Avda Córdoba s/n
City Madrid
ZIP/Postal code 20041
Country Spain
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (31)
GSM737461 MS80 AR
GSM737462 MS83 AR
GSM737463 MS95 AR
BioProject PRJNA141179

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Supplementary file Size Download File type/resource
GSE29746_RAW.tar 73.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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