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Status |
Public on Jun 03, 2011 |
Title |
SW480 Signaling Hub Inhibition |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
In tumor cells, stepwise oncogenic deregulation of signaling cascades induces alterations of cellular morphology and promotes the acquisition of malignant traits. Using a panel of small molecular inhibitors, we established associated gene expression signatures of key signaling hubs.
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Overall design |
SW480 cells were grown in DMEM, 10% FCS, and treated for 24h with the following inhibitors or with solvent (DMSO): SU5402 (42uM); U0126 (10uM), SP600125 (20uM), LY294002 (20uM)
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Contributor(s) |
Morkel M, Leushacke M |
Citation(s) |
21853123 |
Submission date |
Jun 02, 2011 |
Last update date |
Mar 20, 2017 |
Contact name |
Markus Morkel |
E-mail(s) |
morkel@molgen.mpg.de
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Phone |
+493084131332
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Organization name |
Max Planck Institute for Molecular Genetics
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Department |
Developmental Genetics
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Lab |
Tumor Progression
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Street address |
Ihnestr. 73
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City |
Berlin |
State/province |
Berlin |
ZIP/Postal code |
13187 |
Country |
Germany |
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Platforms (1) |
GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
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Samples (15)
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Relations |
BioProject |
PRJNA141107 |