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Series GSE29676 Query DataSets for GSE29676
Status Public on Jul 13, 2011
Title Diagnosis of Alzheimer's Disease Based on Disease-Specific Autoantibody Profiles
Organism Homo sapiens
Experiment type Protein profiling by protein array
Summary Alzheimer's Disease (AD) and Non-Demented Control (NDC) human sera were probed onto human protein microarrays in order to identify differentially expressed autoantibody biomarkers that could be used as diagnostic indicators.
 
Overall design In the study presented here, 50 AD and 40 NDC human serum samples were probed onto human protein microarrays in order to identify differentially expressed autoantibodies. Microarray data was analyzed using several statistical significance algorithms, and autoantibodies that demonstrated significant group prevelance were selected as biomarkers of disease. Prediction classification analysis tested the diagnostic efficacy of the identified biomarkers; and differentiation of AD samples from other neurodegeneratively-diseased and non-neurodegeneratively-diseased controls (Parkinson's disease and breast cancer, respectively) confirmed their specificity.
 
Contributor(s) Nagele RG, Nagele EP, Han M, DeMarshall C, Belinka B
Citation(s) 21826230
Submission date Jun 01, 2011
Last update date Mar 23, 2012
Contact name Robert G Nagele
E-mail(s) nagelero@rowan.edu
Phone 856-566-6083
Organization name UMDNJ-SOM
Department NJISA
Lab Nagele
Street address 2 Medical Center Drive
City Stratford
State/province NJ
ZIP/Postal code 08084
Country USA
 
Platforms (1)
GPL13669 Invitrogen ProtoArray v5.0
Samples (609)
GSM734833 Alzheimer's Disease serum (PD vs. AD) sample 1
GSM734834 Alzheimer's Disease serum (PD vs. AD) sample 2
GSM734835 Alzheimer's Disease serum (PD vs. AD) sample 3
Relations
BioProject PRJNA141195

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29676_Alzheimers.xls.gz 61.1 Mb (ftp)(http) XLS
GSE29676_RAW.tar 1.6 Gb (http)(custom) TAR (of GPR)
Processed data included within Sample table
Processed data are available on Series record
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