NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE29606 Query DataSets for GSE29606
Status Public on Sep 05, 2012
Title Gene expression profiles of effector T cells induced by mTOR inhibition
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To further develop our gene expression approach to treatment of autoimmunity, we have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed upon immunosuppressor treatment responsible for inhibition of T cell effector functions. Human CD4+CD25- cells from healthy donors were pretreated or not with rapamycin and stimulated with anti-CD3 and anti-CD28 for 12h.
 
Overall design mTOR (Mammalian Target of Rapamycin) inhibition-induced gene expression was evaluated in human effector T cells after 1 hour rapamycin pretreatment and compared to vehicle-pretreated cells. Three independent experiments were performed for each of the two different experimental conditions using different donors for each experiment.
 
Contributor(s) Procaccini C, Greco D, Matarese G
Citation(s) 22904304
Submission date May 27, 2011
Last update date Feb 22, 2018
Contact name Dario Greco
E-mail(s) dario.greco@tuni.fi
Organization name Tampere University
Department Faculty of Medicine and Health Technology
Lab Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE)
Street address Arvo ylpön Katu 34
City Tampere
ZIP/Postal code 33520
Country Finland
 
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (6)
GSM733569 Lymphocytes_3/28_rep1
GSM733570 Lymphocytes_3/28_rep2
GSM733571 Lymphocytes_3/28_rep3
This SubSeries is part of SuperSeries:
GSE29608 Gene expression profiles of effector T cells
Relations
BioProject PRJNA153817

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29606_RAW.tar 67.0 Mb (http)(custom) TAR (of GPR)
GSE29606_raw_median_intensity.txt.gz 581.5 Kb (ftp)(http) TXT
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap