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Series GSE28455 Query DataSets for GSE28455
Status Public on Oct 17, 2013
Title Sox2-regulatory networks in embryonic and trophoblast stem cells
Organism Mus musculus
Experiment type Expression profiling by array
Genome binding/occupancy profiling by high throughput sequencing
Summary Sox2 is a pleiotropic transcription factor that regulates self-renewal and differentiation capacity in different types of stem cells, raising the possibility that it regulates similar transcriptional programs controlling common stemness. Embryonic stem (ES) cells and trophoblast stem (TS) cells are two developmentally related types of stem cells, which originate from distinct lineages of peri-implantation embryos. We have found that Sox2 is a critical regulator of self-renewal in both of two stem cells. Genome-wide analysis of Sox2 target genes using Affymetrix Exon Arrays and chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) unraveled that it regulates distinct transcriptional networks in ES and TS cells.
This SuperSeries is composed of the SubSeries listed below.
 
Overall design Refer to individual Series
 
Citation(s) 24120664
Submission date Apr 07, 2011
Last update date May 15, 2019
Contact name Itoshi NIKAIDO
E-mail(s) itoshi.nikaido@riken.jp
Organization name RIKEN
Department Center for Biosystems Dynamics Research
Lab Laboratory for Bioinformatics Research
Street address 2-1 Hirosawa
City Wako
State/province Saitama
ZIP/Postal code 351-0198
Country Japan
 
Platforms (3)
GPL6096 [MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version]
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (50)
GSM703159 Sox2KO ESC Control biological rep1
GSM703160 Sox2KO ESC Control biological rep2
GSM703161 Sox2KO ESC Control biological rep3
This SuperSeries is composed of the following SubSeries:
GSE28451 Conditional knockout of Sox2 in embryonic and trophoblast stem cells.
GSE28452 Induction of trophoblast stem cells from embryonic stem cells by forced repression of Oct3/4.
GSE28453 Dynamics of Sox2 and Esrrb occupancy during the differentiation of embryonic stem cells into trophoblast stem cells.
Relations
BioProject PRJNA139231

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE28455_RAW.tar 1.9 Gb (http)(custom) TAR (of BW, CEL)
SRA Run SelectorHelp
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