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Series GSE28454 Query DataSets for GSE28454
Status Public on Apr 30, 2012
Title Temporal transcriptional changes in human monocytes following acute myocardial infarction: The GerMIFs monocyte expression study
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Monocytes play a central role in the inflammatory response that follows acute myocardial infarction (MI). In order to study phenotypic adaptation of this cell type, we investigated patterns of monocyte gene expression in circulating monocytes at various stages of MI. Circulating monocytes were isolated from venous blood of MI patients at three time points: t1: within 6 hours after onset of chest pain (acute phase), t2: 3 days after MI (subacute phase), t3: 90 days after MI (chronic phase). For comparison, we studied a control group (n=21, data to be submitted later) with stable coronary artery disease.
Using this transcriptomic analysis, we aimed to provide a more comprehensive reference of monocyte biology following acute MI and to aid in the identification of novel pathways and genes influencing the course of MI.
 
Overall design Monocytes play a central role in the inflammatory response that follows acute myocardial infarction (MI). In order to study phenotypic adaptation of this cell type, we investigated patterns of monocyte gene expression in circulating monocytes at various stages of MI. Circulating monocytes were isolated from venous blood of MI patients at three time points: t1: within 6 hours after onset of chest pain (acute phase), t2: 3 days after MI (subacute phase), t3: 90 days after MI (chronic phase). For comparison, we studied a control group (n=21, data to be submitted later) with stable coronary artery disease. Illumina Ref-8 v3.0 microarray arrays were used for whole-genome transcriptional profiling.
 
Contributor(s) Maouche S, Sager HB, Aherrahrou Z, Belz S, Brocheton J, Proust C, Tennstedt S, Ammerlahn H, Riedel C, Stritzke J, Kurowski V, Rice KM, Goodall AH, Hengstenberg C, Ouwehand WH, Samani NJ, Cambien F, Erdmann J, Schunkert1 H, Diemert P
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Submission date Apr 07, 2011
Last update date Mar 20, 2017
Contact name Heribert Schunkert
E-mail(s) Heribert.Schunkert@uk-sh.de
Phone 00494515002501
Fax 00494515006337
URL http://www.innere2-luebeck.uk-sh.de
Organization name Universitaetsklinikums Schleswig-Holstein Luebeck
Department Medizinische Klinik II
Lab Cardiovacsular genomics
Street address Ratzeburger Allee 160
City Luebeck
ZIP/Postal code D-23538
Country Germany
 
Platforms (1)
GPL6883 Illumina HumanRef-8 v3.0 expression beadchip
Samples (76)
GSM703192 Monocyte RNA 6h X4300799014_C_t1
GSM703193 Monocyte RNA 6h X4300799014_E_t1
GSM703194 Monocyte RNA 6h X4300799014_G_t1
Relations
BioProject PRJNA139229

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE28454_RAW.tar 3.9 Mb (http)(custom) TAR
GSE28454_non-normalized.txt.gz 11.7 Mb (ftp)(http) TXT
Processed data included within Sample table

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