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Status |
Public on Dec 02, 2024 |
Title |
Single-Cell Multiomics Profiling Reveals Heterogeneity of Müller Cells in the Oxygen-Induced Retinopathy Model |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing
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Summary |
Retinal neovascularization poses heightened risks of vision loss and blindness. Despite its clinical significance, the molecular mechanisms underlying the pathogenesis of retinal neovascularization remain elusive. This study utilized single-cell multiomics profiling in an oxygen-induced retinopathy (OIR) model to comprehensively investigate the intricate molecular landscape of retinal neovascularization.
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Overall design |
Multiome-seq: Single nuclei were extracted from retinas from postnatal day 17 (P17) mice under the OIR model.Joint snRNA- and scATAC libraries were prepared using the 10x Genomics platform.
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Web link |
https://iovs.arvojournals.org/article.aspx?articleid=2802203
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Contributor(s) |
Yao X, Yan H |
Citation(s) |
39504047 |
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Submission date |
Dec 02, 2024 |
Last update date |
Dec 03, 2024 |
Contact name |
Xueming Yao |
E-mail(s) |
yaoxueming@tmu.edu.cn
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Organization name |
Nankai University
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Street address |
No.94 Weijin Road, Nankai District
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City |
Tianjin |
ZIP/Postal code |
300071 |
Country |
China |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (2) |
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Relations |
BioProject |
PRJNA1193014 |
Supplementary file |
Size |
Download |
File type/resource |
GSE283276_RAW.tar |
1.3 Gb |
(http)(custom) |
TAR (of MTX, TBI, TSV) |
SRA Run Selector |
Raw data are available in SRA |
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