|
| Status |
Public on Jan 01, 2013 |
| Title |
Oxygen regulation of immunogenicity in primary human glioma cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Dendritic Cell (DC) vaccination is a powerful approach for cancer immunotherapy that has recently obtained regulatory approval, and tumor lysate-pulsed DC vaccines are being tested in clinical trials. Tumor cell lysates (TLs) are often generated from cells cultured in atmospheric oxygen (~20% O2), which is roughly four-fold higher than that of the tumor in situ. We analyzed the expression patterns of glioma cells cultured in 5% Oxygen, 20% Oxygen and the primary tumors which the cell cultures were derived.
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| |
|
| Overall design |
Total RNA from primary resected glioma tumors or tumor cells cultured in in either 5% oxygen or 20% oxygen
|
| |
|
| Contributor(s) |
Sarver A |
| Citation(s) |
21908554 |
| Submission date |
Apr 01, 2011 |
| Last update date |
Mar 26, 2020 |
| Contact name |
Aaron Sarver |
| Organization name |
University of Minnesota
|
| Department |
Masonic Cancer Center
|
| Lab |
Biostatistics and Informatics
|
| Street address |
425 East River Road
|
| City |
Minneapolis |
| State/province |
MN |
| ZIP/Postal code |
55455 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
|
| Samples (16)
|
| GSM700434 |
Primary cultured Glioma cells BST001-5-O2-1 |
| GSM700435 |
Primary cultured Glioma cells BST001-5-O2-2 |
| GSM700436 |
Primary cultured Glioma cells BST001-20-O2-2 |
| GSM700437 |
Primary cultured Glioma cells BST001-20-O2-1 |
| GSM700438 |
Primary Glioma tumor BST001-Tissue-1 |
| GSM700439 |
Primary Glioma tumor BST001-Tissue-2 |
| GSM700440 |
Primary Glioma tumor BST001-Tissue-3 |
| GSM700441 |
Primary cultured Glioma cells 3531-5-O2-1 |
| GSM700442 |
Primary cultured Glioma cells 3531-5-O2-2 |
| GSM700443 |
Primary cultured Glioma cells 3531-5-O2-3 |
| GSM700444 |
Primary cultured Glioma cells 3531-20-O2-2 |
| GSM700445 |
Primary cultured Glioma cells 3531-20-O2-3 |
| GSM700446 |
Primary cultured Glioma cells 3531-20-O2-1 |
| GSM700447 |
Primary Glioma tumor 3531-Tissue-1 |
| GSM700448 |
Primary Glioma tumor 3531-Tissue-2 |
| GSM700449 |
Primary Glioma tumor 3531-Tissue-3 |
|
| Relations |
| BioProject |
PRJNA139333 |
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