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Series GSE28168 Query DataSets for GSE28168
Status Public on Dec 31, 2012
Title Differential gene expression in the airway epithelium of beta6 ko mice chronically challenged with OVA
Organism Mus musculus
Experiment type Expression profiling by array
Summary Expression microarrays identified 119 genes that were significantly differentially expressed in the epithelium of WT and β6 KO mice after saline or chronic allergen challenge. PAM clustering revealed two interesting clusters (6 and 8) that we had not identified in previous comparisons by whole lung microarrays. Cluster 6 genes were low at baseline in both WT and β6 KO mice and were increased in WT but not in β6 KO mice after chronic allergen challenge such as Mcpt1. Cluster 8 genes were increased at baseline in β6 KO mice, and included 6 mast cell related genes (cma1, mcpt4, cpa3, mcpt6, tpsab1, il1rl1). The most informative differentially expressed genes identified in microarrays of the epithelial microenvironment were not epithelial genes, but mast cell genes.
Overall design Control and beta6 ko mice (wt-S (4), wt-OVA (4), ko-S (4), ko-OVA (4)) were sensitized and challenged with OVA or saline, airway epithelium were brush-harvested.
Contributor(s) Sheppard D
Citation(s) 22232213
Submission date Mar 24, 2011
Last update date Jan 12, 2017
Contact name Xiaozhu Huang
Organization name UCSF
Department medicine
Street address 1550 4th St. Rock Hall, 5th FL. Rm 545
City San Francisco
ZIP/Postal code 94158
Country USA
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (16)
GSM697607 wt Epithelium_saline_rep1
GSM697608 wt Epithelium_saline_rep2
GSM697609 wt Epithelium_saline_rep3
BioProject PRJNA139517

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE28168_RAW.tar 34.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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