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| Status |
Public on Nov 08, 2024 |
| Title |
Spinal cord single-nuclei RNA sequencing of an EAE mouse model of multiple sclerosis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We used the MOG35-55 peptide induction experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis to determine whether Bruton's tyrosine kinase (BTK) inhibition could attenuate disease-relevant changes to central nervous system gene expression.
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| Overall design |
Lumbar spinal cord was collected from a C57BL/6 experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis. Single nuclei RNA sequencing was then performed. A subset of mice had been treated with an inhibitor of Bruton’s tyrosine kinase (BTK) after disease induction.
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| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 06, 2024 |
| Last update date |
Nov 08, 2024 |
| Contact name |
Timothy R Hammond |
| Organization name |
Sanofi
|
| Street address |
350 Water Street
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02141 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA1182672 |
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