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| Status |
Public on Nov 06, 2024 |
| Title |
Conserved DNA Methylation Signatures in the Prefrontal Cortex of Newborn and Juvenile Guinea Pigs Following Antenatal Betamethasone Exposure |
| Organism |
Cavia porcellus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
We investigated the effect of antenatal corticosteroid exposure (ACS) on the DNA methylation patterns in the prefrontal cortex (PFC) of female guinea pig offspring. Guinea pig dams were treated with saline or betamethasone on gestational days 50/51. PFC was collected from newborn (post-natal day 1) and juvenile (PND 14) offspring. Methylation assessment using genomic DNA was performed with reduced representation bisulfite sequencing techniques.
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| Overall design |
Differential DNA methylation in the prefrontal cortex of newborn female guinea pig offspring was assessed to compare profiles between Betamethasone and saline control exposures. The PND1 cohort has n=7 per treatment condition, total of 14. The PND14 cohort has n=7 in the saline group and n=6 in the Betamethasone group, to a total of 13.
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| Contributor(s) |
Kim B, Kostaki A, Matthews S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Oct 30, 2024 |
| Last update date |
Nov 06, 2024 |
| Contact name |
Stephen Matthews |
| Organization name |
University of Toronto
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| Street address |
1 King's College Circle, Rm 3302
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| City |
Toronto |
| ZIP/Postal code |
M5S1A8 |
| Country |
Canada |
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| Platforms (1) |
| GPL29163 |
Illumina NextSeq 500 (Cavia porcellus) |
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| Samples (27)
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| GSM8604942 |
pnd1 pfc, saline, rep4 |
| GSM8604943 |
pnd1 pfc, saline, rep5 |
| GSM8604944 |
pnd1 pfc, saline, rep6 |
| GSM8604945 |
pnd1 pfc, saline, rep7 |
| GSM8604946 |
pnd1 pfc, beta, rep1 |
| GSM8604947 |
pnd1 pfc, beta, rep2 |
| GSM8604948 |
pnd1 pfc, beta, rep3 |
| GSM8604949 |
pnd1 pfc, beta, rep4 |
| GSM8604950 |
pnd1 pfc, beta, rep5 |
| GSM8604951 |
pnd1 pfc, beta, rep6 |
| GSM8604952 |
pnd1 pfc, beta, rep7 |
| GSM8604953 |
pnd14pfc, saline, rep1 |
| GSM8604954 |
pnd14pfc, saline, rep2 |
| GSM8604955 |
pnd14pfc, saline, rep3 |
| GSM8604956 |
pnd14pfc, saline, rep4 |
| GSM8604957 |
pnd14pfc, saline, rep5 |
| GSM8604958 |
pnd14pfc, saline, rep6 |
| GSM8604959 |
pnd14pfc, saline, rep7 |
| GSM8604960 |
pnd14pfc, beta, rep1 |
| GSM8604961 |
pnd14pfc, beta, rep2 |
| GSM8604962 |
pnd14pfc, beta, rep3 |
| GSM8604963 |
pnd14pfc, beta, rep4 |
| GSM8604964 |
pnd14pfc, beta, rep5 |
| GSM8604965 |
pnd14pfc, beta, rep6 |
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| Relations |
| BioProject |
PRJNA1180102 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE280726_pnd14pfc_DMC.txt.gz |
65.3 Kb |
(ftp)(http) |
TXT |
| GSE280726_pnd1pfc_DMC.txt.gz |
92.5 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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