GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE27965 Query DataSets for GSE27965
Status Public on Mar 17, 2011
Title CNVs in spermatogenic failure
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary To determine the involvement of Copy Number Variants (CNVs) in the origin of male infertility, patients with idiopathic severe oligozoospermia, Sertoli-cell-only syndrome and controls with normozoospermia were analysed by array CGH using the 244A/400K array sets (Agilent Technologies).
Overall design Comparison of 89 infertile male patients with severe oligozoospermia (≤5 x Mill./ml sperm concentration and ≤10 Mill. total sperm count) and 37 with azoospermia due to complete, bilateral Sertoli-cell-only syndrome (SCOS) with 100 healthy controls with normal semen parameters (≥20 Mill./ml sperm concentration, ≥40 Mill. total sperm count, ≥2 ml semen volume, ≥50% of a+b or ≥25% a motility, high percentage of normal forms (≥10%)). Patients with recurring, patient-specific and mostly private, sex-chromosomal CNVs (29 with OAT and 17 with SCOS) are reported as possibly causing spermatogenic failure.
Contributor(s) Tüttelmann F, Röpke A
Citation(s) 21559371
Submission date Mar 15, 2011
Last update date Mar 21, 2017
Contact name Frank Tüttelmann
Organization name Institute of Human Genetics
Department University of Münster
Street address Vesaliusweg 12-14
City Münster
ZIP/Postal code 48149
Country Germany
Platforms (2)
GPL4091 Agilent-014693 Human Genome CGH Microarray 244A (Feature number version)
GPL9777 Agilent-021850 SurePrint G3 Human CGH Microarray (Feature Number version)
Samples (46)
GSM691541 Patient with OAT 1
GSM691542 Patient with OAT 2
GSM691543 Patient with OAT 3
BioProject PRJNA137757

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27965_RAW.tar 2.2 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap