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| Status |
Public on Aug 04, 2024 |
| Title |
POSTN secreted from glioblastoma stem cells can recruit microglia and upregulate CD70 expression in microglia through the αVβ3/PI3K/AKT/NFκB pathway |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Our findings revealed that POSTN secreted from GSCs can recruit microglia and upregulate CD70 expression in microglia through the αVβ3/PI3K/AKT/NFκB pathway, which in turn promotes Treg development and functionality and supports the formation of an immunosuppressive tumor microenvironment.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seg data of HMC3 cells treated with PBS or human recombinant POSTN.
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| Contributor(s) |
Wang H, Zhou Y |
| Citation missing |
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| |
| Submission date |
Jul 30, 2024 |
| Last update date |
Aug 05, 2024 |
| Contact name |
Hao Wang |
| E-mail(s) |
nwanghao1107@gmail.com
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| Phone |
8618862186421
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| Organization name |
The First Affiliated Hospital of Soochow University
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| Department |
Department of Neurosurgery & Brain and Nerve Research Laboratory
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| Street address |
899 Pinghai Road
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| City |
Soochow |
| State/province |
Jiangsu |
| ZIP/Postal code |
215006 |
| Country |
China |
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| Platforms (1) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA1141973 |
