NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE269888 Query DataSets for GSE269888
Status Public on Jun 26, 2024
Title Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth [scRNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Here, we sought to understand the function of stromal interleukin-33 (IL-33) in PanIN and PDA. We collected pancreatic tissues from various mouse models of PanIN and PDA for single cell RNA sequencing to assess IL-33 expression across the microenviornment. We also implanted syngeneic orthotopic pancreatic tumors into mice harboring a conditional stromal IL-33 knockout and sequenced the resulting tumors.
 
Overall design Pancreata from various mouse models of pancreatic tumorigenesis (spontaneous or orthotopic injection) collected and subjected to single cell RNA sequencing.
 
Contributor(s) Donahue KL, Zhang Y, Lasse-Opsahl EL, Pasca di Magliano M
Citation(s) 38958646
Submission date Jun 14, 2024
Last update date Oct 15, 2024
Contact name Marina Pasca di Magliano
E-mail(s) marinapa@umich.edu
Organization name University of Michigan Medical School
Street address 1500 E Medical Center Dr
City Ann Arbor
State/province MI
ZIP/Postal code 48103
Country USA
 
Platforms (2)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (11)
GSM8329614 KC PanIN 1
GSM8329615 KC PanIN 2
GSM8329616 iKrasG12D 5 weeks ON
Relations
BioProject PRJNA1124072

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE269888_RAW.tar 1.2 Gb (http)(custom) TAR (of H5)
SRA Run SelectorHelp
Raw data are available in SRA

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap