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Series GSE267454 Query DataSets for GSE267454
Status Public on May 25, 2024
Title sRNA-seq of Aspergillus fumigatus RNAi double knockouts
Organism Aspergillus fumigatus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary The RNA interference (RNAi) pathway has evolved numerous functionalities in eukaryotes, with many on display in Kingdom Fungi. RNAi can regulate gene expression, facilitate drug resistance, or even be altogether lost to improve virulence potential in some fungal pathogens. In the WHO fungal priority pathogen, Aspergillus fumigatus, the RNAi system is known to be intact and functional. To extend our limited understanding of A. fumigatus RNAi, we performed a multi-condition sRNA-seq analysis comparing expression of several RNAi double knockout mutants with the wild-type strain in conidia and mycelium grown for 24 or 48 hours.
 
Overall design Small RNA profiling analysis of RNAi double knockouts (𝚫dclA/B, 𝚫ppdA/B, 𝚫rrpA/B) in the RNAi pathway of Aspergillus fumigatus conidia, 24-h-mycelium, and 48-h-mycelium.
Web link https://www.biorxiv.org/content/10.1101/2024.05.24.595671v1
 
Contributor(s) Blango MG, Kelani AA, Pan X
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Submission date May 14, 2024
Last update date May 25, 2024
Contact name Matthew George Blango
Organization name Leibniz Institute for Natural Product Research and Infection Biology
Department Junior Resaerch Group RNA Biology of Fungal Infections
Street address Adolf-Reichwein-Str. 23
City Jena
ZIP/Postal code 07745
Country Germany
 
Platforms (1)
GPL33056 Illumina NovaSeq 6000 (Aspergillus fumigatus)
Samples (36)
GSM8266959 Wild-type_conidia_1
GSM8266960 Wild-type_conidia_2
GSM8266961 Wild-type_conidia_3
Relations
BioProject PRJNA1111541

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE267454_sRNA_processed.csv.gz 2.9 Mb (ftp)(http) CSV
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Raw data are available in SRA

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