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Series GSE264733 Query DataSets for GSE264733
Status Public on Jun 06, 2024
Title Effect of depletion of C10orf71 on gene expression in hearts from embryonic mice at E18.5 and adult mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To explore the specific functional and cellular processes that affected by the mC10orf71 deletion, we compared total RNA expression in hearts from E18.5. Gene Ontology (GO) enrichment analysis showed that down-regulated genes were not significantly enriched in any biological process. The 327 genes up-regulated in KO mice were enriched for energy generation, electron transport chain and ATP synthesis, and many of them are encoded by mitochondrial DNA. These changes were likely to be a compensatory response to the impaired morphogenesis and dysfunction of the KO hearts. Then, we performed RNA-seq on hearts of adult WT and KO mice. GO analysis of down-regulated genes identified two categories of biological processes: mRNA processing/splicing and muscle cell differentiation/contraction.
 
Overall design We performed gene expression analysis using data obtained from RNA-seq of 4 WT mice and 4 KO mice at two time points
 
Contributor(s) Li Y, Li Y
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Submission date Apr 23, 2024
Last update date Jun 06, 2024
Contact name Yang Li
E-mail(s) liyanganzhen@126.com
Phone 86+13811892074
Organization name Beijing Anzhen Hospital
Street address Anzhen Road, Chaoyang District
City Beijing
ZIP/Postal code 100029
Country China
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (16)
GSM8226827 WT1, E18.5, heart
GSM8226828 WT2, E18.5, heart
GSM8226829 WT3, E18.5, heart
Relations
BioProject PRJNA1103880

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE264733_E18.5.txt.gz 3.3 Mb (ftp)(http) TXT
GSE264733_adult.txt.gz 3.3 Mb (ftp)(http) TXT
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Raw data are available in SRA

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