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Series GSE264253 Query DataSets for GSE264253
Status Public on May 06, 2024
Title IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions are the leading cause of death in the world. The most common and effective means to reduce these major adverse cardiovascular events (MACE), including myocardial infarction (MI) and stroke, is aggressive lipid lowering via a combination of drugs and dietary modifications. However, little is known regarding the effects of reducing dietary lipids on the composition and stability of advanced atherosclerotic lesions, the mechanisms that regulate these processes, and what therapeutic approaches might augment the benefits of lipid lowering.
Overall design scRNA-seq of atherosclerotic plaques of Apoe-/- mouse (with or without specific SMC with Ab or IgG against Il1b)
Contributor(s) Karnewar S, Karnewar V, Deaton R, Shankman LS, Benavente ED, Williams CM, Bradley X, Alencar GF, Bulut GB, Kirmani S, Baylis RA, Zunder ER, den Ruijter HM, Pasterkamp G, Owens GK
Citation(s) 38695167
Submission date Apr 17, 2024
Last update date May 07, 2024
Contact name Gary K Owens
Organization name University of Virginia
Street address 415 Lane Road MR5 Building Room 1322
City Charlottesville
State/province VA
ZIP/Postal code 22908
Country USA
Platforms (1)
GPL16417 Illumina MiSeq (Mus musculus)
Samples (8)
GSM8215026 Ab_CD31
GSM8215027 Ab_CD45
GSM8215028 Ab_Live
BioProject PRJNA1101548

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Supplementary file Size Download File type/resource
GSE264253_RAW.tar 57.8 Mb (http)(custom) TAR (of TAR)
SRA Run SelectorHelp
Raw data are available in SRA

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