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| Status |
Public on Apr 15, 2024 |
| Title |
Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in Desmoplastic Small Round Cell Tumors [scRNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, aggressive sarcoma driven by the EWSR1-WT1 chimeric transcription factor. Despite this unique oncogenic driver, DSRCT displays a polyphenotypic differentiation of unknown causality. Using single-cell multi-omics on samples from patients, we find that DSRCT tumor cells cluster into consistant subpopulations with partially overlapping lineage- and metabolism-related transcriptional programs.
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| Overall design |
Fresh tumor material from patients with DSRCT was profiled using the 3’-end scRNA-seq 10x Genomics Chromium assay.
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Raw data were not submitted due to privacy concerns.
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| Contributor(s) |
Henon C, Vibert J, Colmet-Daage L, Postel-Vinay S |
| Citation(s) |
38781959 |
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| Submission date |
Apr 09, 2024 |
| Last update date |
Aug 02, 2024 |
| Contact name |
Clémence Henon |
| E-mail(s) |
clemence.henon@gustaveroussy.fr
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| Organization name |
Gustave Roussy
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| Street address |
114 rue Edouard Vaillant
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| City |
Villejuif |
| ZIP/Postal code |
94800 |
| Country |
France |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (11)
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| GSM8193969 |
GR2 patient, site 4, scRNAseq |
| GSM8193970 |
GR4 patient, scRNAseq |
| GSM8193971 |
GR4 patient, post chemotherapy, scRNAseq |
| GSM8193972 |
IC patient, site 1, scRNAseq |
| GSM8193973 |
IC patient, site 2, scRNAseq |
| GSM8193974 |
IC patient, site 3, scRNAseq |
| GSM8193975 |
GR7 patient, site 1, scRNAseq |
| GSM8193976 |
GR7 patient, site 2, scRNAseq |
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| This SubSeries is part of SuperSeries: |
| GSE263523 |
Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in Desmoplastic Small Round Cell Tumors |
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| Relations |
| BioProject |
PRJNA1097964 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE263521_RAW.tar |
883.1 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
| Raw data not provided for this record |
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