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Series GSE26349 Query DataSets for GSE26349
Status Public on Mar 31, 2011
Title Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis
Organism Homo sapiens
Experiment type Expression profiling by array
Methylation profiling by array
Summary Cancer-specific changes in DNA methylation can alter genetic stability, genomic structure, and gene expression. Promoter CpG island methylation can result in transcriptional silencing and plays an important role in the oncogenic process. We used genome-wide analysis to characterize the methylomes of breast cancers with diverse metastatic behavior. Here, we describe the identification of novel groups of breast tumors characterized by the presence or absence of coordinate hypermethylation at a large number of genes, demonstrating the existence of a breast-CpG island methylator phenotype (B-CIMP). B-CIMP imparts a distinct epigenomic profile and is a strong determinant of metastatic potential.
Overall design Gene Expression Samples (GSM647057-GSM647077): Twenty-one breast cancer primary samples were analyzed. There are 10 CIMP positive and 11 CIMP negative samples.

Methylation Profiling Samples (GSM651372-GSM651410): Thirty-nine breast cancer primary samples were analyzed. There are 17 CIMP positive and 22 CIMP negative samples.
Contributor(s) Fang F, Chan T
Citation(s) 21430268
Submission date Dec 29, 2010
Last update date Dec 06, 2018
Contact name FANG FANG
Phone 646-8882783
Fax 646-8882595
Organization name Memorial Sloan-Kettering Cancer Center
Department The Human Oncology and Pathogenesis Program
Lab Timothy Chan
Street address 1275 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
Platforms (2)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
GPL8490 Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)
Samples (60)
GSM647057 E2
GSM647058 E19
GSM647059 E21
BioProject PRJNA136729

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26349_RAW.tar 44.0 Mb (http)(custom) TAR (of CEL)
GSE26349_non-normalized.txt.gz 19.1 Mb (ftp)(http) TXT
Processed data included within Sample table

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