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Series GSE263190 Query DataSets for GSE263190
Status Public on May 29, 2024
Title Effect of whole-body deletion of Gclc on the liver
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The rate-limiting step in glutathione (GSH) synthesis is controlled by glutamate-cysteine ligase catalytic subunit. To investigate the impact of GSH in vivo, we induced a deletion of Gclc using a Gclcf/f Rosa26-CreERT2 mouse model and harvested liver tissue for analysis.
 
Overall design Liver tissue was harvested from WT and KO mice approximately two weeks after treatment with tamoxifen to induce Cre activity and Gclc deletion.
 
Contributor(s) Harris IS, Asantewaa G
Citation(s) 39034312
Submission date Apr 03, 2024
Last update date Aug 16, 2024
Contact name Isaac Spencer Harris
E-mail(s) isaac_harris@urmc.rochester.edu
Phone 8572348624
Organization name University of Rochester Medical Center
Department Department of Biomedical Genetics
Lab Harris Lab
Street address 601 Elmwood Ave
City Rochester
State/province New York
ZIP/Postal code 14642
Country USA
 
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (32)
GSM8187338 Gclc WT 1 Batch 1-1
GSM8187339 Gclc WT 1 Batch 2-1
GSM8187340 Gclc WT 1 Batch 1-2
Relations
BioProject PRJNA1096112

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE263190_Harris_WT_Gclc_normalized_counts.xlsx 4.3 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA

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