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Status |
Public on May 29, 2024 |
Title |
Effect of whole-body deletion of Gclc on the liver |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
The rate-limiting step in glutathione (GSH) synthesis is controlled by glutamate-cysteine ligase catalytic subunit. To investigate the impact of GSH in vivo, we induced a deletion of Gclc using a Gclcf/f Rosa26-CreERT2 mouse model and harvested liver tissue for analysis.
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Overall design |
Liver tissue was harvested from WT and KO mice approximately two weeks after treatment with tamoxifen to induce Cre activity and Gclc deletion.
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Contributor(s) |
Harris IS, Asantewaa G |
Citation(s) |
39034312 |
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Submission date |
Apr 03, 2024 |
Last update date |
Aug 16, 2024 |
Contact name |
Isaac Spencer Harris |
E-mail(s) |
isaac_harris@urmc.rochester.edu
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Phone |
8572348624
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Organization name |
University of Rochester Medical Center
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Department |
Department of Biomedical Genetics
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Lab |
Harris Lab
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Street address |
601 Elmwood Ave
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City |
Rochester |
State/province |
New York |
ZIP/Postal code |
14642 |
Country |
USA |
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Platforms (1) |
GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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Samples (32)
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Relations |
BioProject |
PRJNA1096112 |