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Status |
Public on Jul 05, 2024 |
Title |
Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function |
Organism |
Homo sapiens |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
We used bulk and single-cell ATAC-seq to measure chromatin accessibilty in human kidneys. This allowed us to define candidate cis-regulatory elements of each human kidney cell type and identify the role of podocyte and tubule regulatory elements in human kidney function.
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Overall design |
Single cell ATAC-sequencing of 3 human kidneys. Single cell ATAC-sequencing was performed on cortex from all 3 kidneys and medulla from two of the kidneys. Bulk ATAC-sequencing from the cortex of one human kidney was also performed.
**Please note that the records have been updated with additional data on Aug 8, 2024.****
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Contributor(s) |
Loeb GB, Reiter JF |
Citation(s) |
39256582 |
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Submission date |
Apr 01, 2024 |
Last update date |
Sep 26, 2024 |
Contact name |
Gabriel Loeb |
E-mail(s) |
gabriel.loeb@ucsf.edu
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Organization name |
UCSF
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Department |
Medicine
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Street address |
555 Mission Bay Blvd South, Rm 382H
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City |
San Francisco |
State/province |
CA |
ZIP/Postal code |
94143 |
Country |
USA |
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Platforms (1) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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Samples (6)
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Relations |
BioProject |
PRJNA1094933 |