GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE26232 Query DataSets for GSE26232
Status Public on Jan 29, 2013
Title Genomic profiles vary with race and subtype in young African American and European American breast cancer (SNP)
Organism Homo sapiens
Experiment type SNP genotyping by SNP array
Genome variation profiling by SNP array
Summary In the United States, African-American (AA) women are more likely to develop early-onset breast cancer and have historically poorer outcomes due to this disease compared to European-American (EA) women. Here, we analyzed genomic profiles of breast tumors from young women (<50 years old), matched by tumor subtype, histological grade, and ethnicity (African-American, AA, compared to European-American, EA). DNA copy number alterations (CNAs) were analyzed on the Affymetrix Human SNP Array v 6.0 platform. The study provides insight into the genetic component of ethnicity-related breast cancer health disparities.
Overall design DNA copy number alterations (CNAs) and genotypes were analyzed using the Affymetrix SNP 6.0 platform.
Breast tumor samples from young women (< 50 years old) were matched as follows: a matched pair consists of one AA and one EA sample, matched for tumor grade and tumor subtype (based on immunohistochemical analysis of ER, PR, and HER2 status). DNA from forty-four samples (22 AA, 22 EA) was analyzed on the Affymetrix SNP 6.0 array according to manufacturer’s directions.
Contributor(s) Farmer TL, Strong TV
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Dec 21, 2010
Last update date Nov 27, 2018
Contact name Theresa V Strong
Phone 205-975-9878
Fax 205-934-9511
Organization name University of Alabama at Birmingham
Department Medicine
Lab Strong
Street address 1530 3rd Avenue South
City Birmingham
State/province AL
ZIP/Postal code 35294
Country USA
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (49)
GSM805437 Normal (SNP)
GSM805438 Tumor sample 104 (SNP)
GSM805439 Tumor sample 112 (SNP)
This SubSeries is part of SuperSeries:
GSE26233 Genomic profiles vary with race and subtype in young African American and European American breast cancer
BioProject PRJNA142335

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26232_ EA_CNV_HER2+ER-_898.txt.gz 22.1 Kb (ftp)(http) TXT
GSE26232_ EA_CNV_LumA_AAnormal_1195.txt.gz 27.7 Kb (ftp)(http) TXT
GSE26232_AA_CNV_HER2+ER-_AAnormal_191.txt.gz 5.2 Kb (ftp)(http) TXT
GSE26232_AA_CNV_LumA_AAnormal_15886.txt.gz 341.8 Kb (ftp)(http) TXT
GSE26232_AA_CNV_LumB_AAnormal_1055.txt.gz 25.5 Kb (ftp)(http) TXT
GSE26232_AA_CNV_basal_AAnormal_33442.txt.gz 721.8 Kb (ftp)(http) TXT
GSE26232_EA_CNV_LumB_AAnormal_924.txt.gz 22.3 Kb (ftp)(http) TXT
GSE26232_EA_CNV_basal_AAnormal_8427.txt.gz 176.0 Kb (ftp)(http) TXT
GSE26232_RAW.tar 2.0 Gb (http)(custom) TAR (of CEL, CHP)
GSE26232_SampleID_for_CNAcalls.txt.gz 268 b (ftp)(http) TXT
Processed data included within Sample table
Processed data provided as supplementary file
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap