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| Status |
Public on Mar 18, 2024 |
| Title |
3M-Brazzein, a Natural Sugar Substitute, can Suppress Metabolic Disorders, NAFLD, and Depression-like Behaviors in Diabetic Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The increasing consumption of sugar-sweetened beverages (SSBs) in modern society has enhanced the epidemic of obesity, metabolic disorders, and mental illnesses. Therefore, the current study investigated the potential of 3M-Brazzein as a promising natural sugar substitute. 4-weeks-old leptin receptor knockout mice (db/db) were supplied with water, 10% sucrose solution, or a 3M-Brazzein solution respectively for 16 weeks. Chronic consumption of 3M-Brazzein did not cause any degeneration of adipogenesis, insulin resistance, hepatic lipogenesis, and depression-like behaviors. However, 10% sucrose consumed mice exhibited completely different outcomes. Furthermore, the mRNA expression levels of GLUT2, SREBF-1, and PPARĪ³ in liver were significantly increased in knockout mice supplied with the 10% sucrose solution, thereby the excessive sucrose consumption induced severe obesity, impairment of glucose homeostasis, non-alcoholic fatty liver disease (NAFLD), and major depressive disorder in them. Consequently, the present study demonstrated the positive effects of 3M-Brazzein on various health problems prevalent in the modern world, and suggests some genetic clues related to the pathogenesis of NAFLD and major depressive disorder.
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| Overall design |
A study was performed to examine the effects on brain and liver health following the consumption of 3M-Brazzein and sucrose in a leptin receptor knockout model (db/db)
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| Contributor(s) |
Hong S, Kong K, Hong S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Mar 15, 2024 |
| Last update date |
Mar 18, 2024 |
| Contact name |
sungguan hong |
| E-mail(s) |
sungguanhong@cau.ac.kr
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| Organization name |
Chung-Ang
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| Department |
Chemistry
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| Street address |
84, Heukseok-ro, Dongjak-gu, Seoul, 104-407
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| City |
seoul |
| State/province |
none |
| ZIP/Postal code |
06974 |
| Country |
South Korea |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (24)
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| GSM8149636 |
Brain, sucrose, db/+, rep2 |
| GSM8149637 |
Brain, water, db/+, rep1 |
| GSM8149638 |
Brain, water, db/+, rep2 |
| GSM8149639 |
Brain, brazzein, db/db, rep1 |
| GSM8149640 |
Brain, brazzein, db/db, rep2 |
| GSM8149641 |
Brain, sucrose, db/db, rep1 |
| GSM8149642 |
Brain, sucrose, db/db, rep2 |
| GSM8149643 |
Brain, water, db/db, rep1 |
| GSM8149644 |
Brain, water, db/db, rep2 |
| GSM8149645 |
Liver, brazzein, db/+, rep1 |
| GSM8149646 |
Liver, brazzein, db/+, rep2 |
| GSM8149647 |
Liver, sucrose, db/+, rep1 |
| GSM8149648 |
Liver, sucrose, db/+, rep2 |
| GSM8149649 |
Liver, water, db/+, rep1 |
| GSM8149650 |
Liver, water, db/+, rep2 |
| GSM8149651 |
Liver, brazzein, db/db, rep1 |
| GSM8149652 |
Liver, brazzein, db/db, rep2 |
| GSM8149653 |
Liver, sucrose, db/db, rep1 |
| GSM8149654 |
Liver, sucrose, db/db, rep2 |
| GSM8149655 |
Liver, water, db/db, rep1 |
| GSM8149656 |
Liver, water, db/db, rep2 |
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| Relations |
| BioProject |
PRJNA1088492 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE261723_RAW.tar |
4.6 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE261723_gene_expression_fpkm.txt.gz |
5.6 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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