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Series GSE261688 Query DataSets for GSE261688
Status Public on Apr 17, 2024
Title Expression data from adipose tissue macrophages of mice with or without moderate aerobic exercise
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Non-coding RNA profiling by array
Summary ATMs, which can constitute up to 50% of the cells in adipose tissue of obese mice 5, play a pivotal role in both metabolic and immune regulation of adipose tissue. This is particularly evident in both healthy states and in conditions associated with metabolic syndrome.
To delve into the precise mechanisms of the ATMs in response to exercise, we utilized exercise-induced primary ATMs and miRNAs microarray to investigate the effects of an 8-week aerobic exercise training on ATMs. Following the exercise regimen, ATMs were sorted using flow cytometer and subsequently analyzed through bioinformatics analysis to identify changes in miRNA expression.
Overall design C57BL/6 mice were randomly assigned to either a sedentary (S) or an exercise (E) group. The S group remained inactive, while the E group underwent a one-week treadmill adaptation, followed by an 8-week aerobic treadmill exercise protocol (60 min/ day, 5 days/ week, at 65%-75% VO2max). Post-training, to investigate the effects of exercise in ATMs at the molecular level, miRNA microarray analysis was performed, followed by bioinformatic analysis.
Contributor(s) Qin F, Huang W
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Submission date Mar 15, 2024
Last update date Apr 18, 2024
Contact name Wenbai Huang
Phone 15872366216
Organization name Jinan University
Department School of Physical Education
Street address 601 Huangpu Ave. Tianhe Dist.
City Guangzhou
State/province Guangdong
ZIP/Postal code 510632
Country China
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (6)
GSM8148803 Sedentary_ATMs_Biological_rep_1
GSM8148804 Sedentary_ATMs_Biological_rep_2
GSM8148805 Sedentary_ATMs_Biological_rep_3
BioProject PRJNA1088427

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Supplementary file Size Download File type/resource
GSE261688_RAW.tar 3.4 Mb (http)(custom) TAR (of CEL)

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