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Series GSE261613 Query DataSets for GSE261613
Status Public on May 26, 2024
Title The effect of RVG-SCMH1-Evs treatment on photothrombotic (PT) stroke mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Metabolic dysfunction is considered a key event after ischemic stroke. However, the underlying mechanisms of metabolic disorders in cerebral ischemia is unknown. Circular RNA SCMH1 (circSCMH1), a circular RNA that has been reported to function in brain repair after stroke, was confirmed to be involved in metabolic disorders. circSCMH1 was delivered by rabies virus glycoprotein (RVG)-modified sxtracellular vesicle. Mechanistically, circSCMH1 decreased kynurenine 3-monooxygenase (KMO) expression, a key enzyme in kynurenine metabolism. Our findings suggested that circSCMH1 inhibited KMO expression, providing insight into the mechanism by which circSCMH1 promotes stroke recovery.
 
Overall design To investigate the mechanism of circular RNA SCMH1 in functional recovery of photothrombotic (PT) stroke mice.
 
Contributor(s) Wang Y
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Mar 14, 2024
Last update date May 26, 2024
Contact name Yu Wang
E-mail(s) 230218469@seu.edu.cn
Phone 13913860389
Organization name Southeast University
Department Department of Pharmacology
Lab Honghong yao's lab
Street address Dingjiaqiao 87
City Nanjing
State/province Jiangsu
ZIP/Postal code 210009
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (12)
GSM8147453 Mouse,Sham-Vector,rep1
GSM8147454 Mouse,Sham-Vector,rep2
GSM8147455 Mouse,Sham-Vector,rep3
Relations
BioProject PRJNA1088110

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE261613_1_genes_fpkm_expression.xlsx 8.9 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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