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Series GSE26034 Query DataSets for GSE26034
Status Public on Dec 10, 2013
Title Affymetrix SNP6.0 array data for different clinical outcomes of HBV infection
Organism Homo sapiens
Experiment type SNP genotyping by SNP array
Summary Chronic hepatitis B virus (HBV) infection is a serious global public health problem. To identify susceptibility loci for disease progression of HBV infection, we performed this genome-wide association study using DNA pools of case and control constructed by progressed HBV carriers (acute liver failure, liver cirrhosis, hepatocellular carcinoma) and asymptomatic HBV carriers separately. Performing GWAS on pools of DNA samples is an effective strategy to reduce the costs of studies and pooling DNA has been shown to be an efficient method to select candidate susceptibility loci for follow-up by individual genotyping.
Overall design Affymetrix Genome-Wide Human Mapping SNP6.0 Arrays were performed for DNA pools, which were constructed by pooling 120 ng DNA from each participant. Four independent pools were created: case A was acute liver failure group (n = 86), case B was liver cirrhosis group (n = 88), case C was hepatocellular carcinoma group (n = 90) and case D was asymptomatic HBV carriers (n = 66) that was considered as control. Twelve chips (each pool was replicated in triplicate) were finished according to the manufacturer's instruction.
Contributor(s) Liu L, Lin J, Yao J, Li J, He X, Chang Y
Citation(s) 22004137
Submission date Dec 13, 2010
Last update date Nov 27, 2018
Contact name Lin Ju-Sheng
Phone 86-27-83663661
Organization name Tongji Hospital
Department Gastroenterology
Lab Institute of Liver Disease
Street address 1095 Jiefang Road
City Wuhan
State/province Hubei
ZIP/Postal code 430030
Country China
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (12)
GSM639381 HBV - related acute liver failure group rep1
GSM639382 HBV - related acute liver failure group rep2
GSM639383 HBV - related acute liver failure group rep3
BioProject PRJNA135503

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26034_RAW.tar 524.4 Mb (http)(custom) TAR (of CEL, TXT)
Processed data included within Sample table
Processed data provided as supplementary file

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