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Series GSE25744 Query DataSets for GSE25744
Status Public on Jan 20, 2011
Title Comparative analysis of hESCs and iPSCs-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Two independent protocols for deriving HLCs from hESCs and iPSCs were adopted and further characterization included immunocytochemistry, real-time RT-PCR, and in vitro functional assays. Comparative microarray-based gene expression profiling was conducted on these cells and compared to the transcriptomes of human fetal liver and adult liver progenitors. HLCs derived from hESCs and hiPSCs showed significant functional similarities, similar expression of genes important for liver physiology and common pathways. However, specific differences between the two cell types could be observed.
 
Overall design Total RNA obtained from undifferentiated hESCs, iPSCs, HLCs (hepatocyte-like cells)-derived from hESCs and iPSCs, fetal forskin fibroblasts and fetal liver.
 
Contributor(s) Justyna J
Citation(s) 21162674
Submission date Dec 01, 2010
Last update date Mar 20, 2017
Contact name Justyna Jozefczuk
E-mail(s) jagodzin@molgen.mpg.de
Organization name Max Planck Institute for Molecular Genetics
Department Vertebrate Genomics
Street address Ihnestrasse 63
City Berlin
ZIP/Postal code 14195
Country Germany
 
Platforms (1)
GPL6883 Illumina HumanRef-8 v3.0 expression beadchip
Samples (32)
GSM632609 hESCs_Passage 53_replicate 1
GSM632610 hESCs_Passage 53_replicate 2
GSM632611 hESCs_Passage 53_replicate 3
Relations
BioProject PRJNA134097

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25744_RAW.tar 3.9 Mb (http)(custom) TAR
GSE25744_non-normalized.txt.gz 3.3 Mb (ftp)(http) TXT
Processed data included within Sample table

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