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Series GSE255233 Query DataSets for GSE255233
Status Public on Apr 04, 2024
Title RNA-Seq, WGS, WXS of mouse myeloma tumors derived from Vk*MYC transgenic mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Comprehensive genomic analysis (WXS, WGS, RNAseq) identifies shared pathways of progression between human and mouse myeloma.
Overall design De novo myeloma tumors develop in aged Vk*MYC MYC transgenic mice (summarized by "_O_" in sample name). They may be located in extramedullary locations such as spleen ("_EM_"), or intramedullary in the bone marrow ("_BM_"). They can be passaged in recipient mice ("_R_"). Rarely we are able to establish cell lines that can grow in vitro ("_V_"). Tumors from the mice undergo CD138-selection and are analyzed by RNA-Seq, WGS and WXS
Contributor(s) Bergsagel L, Chesi M
Citation(s) 38714690
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 CA234181 Credentialing a Genetically Engineered Clinically-Relevant Mouse Model of Multiple Myeloma Mayo Clinic Arizona Marta Chesi
P50 CA186781 Mayo Clinic Multiple Myeloma SPORE Mayo Clinic Arizona Peter Leif Bergsagel
BioProject PRJNA938752
Submission date Feb 06, 2024
Last update date May 08, 2024
Contact name Peter Leif Bergsagel
Organization name Mayo Clinic
Street address 13400 E Shea Blvd
City Scottsdale
State/province Arizona
ZIP/Postal code 85259
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (195)
GSM8066996 RNA-Seq of MDR33167 de novo tumor from MDRnull mice harvested from spleen
GSM8066997 RNA-Seq of Vk12598 growing in vitro
GSM8066998 RNA-Seq of Vk12653 growing in vitro

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE255233_TPM_allsamples.txt.gz 3.4 Mb (ftp)(http) TXT
GSE255233_TPM_filtered_allsamples.txt.gz 3.6 Mb (ftp)(http) TXT
GSE255233_igv_cna_penalty_0.seg.txt.gz 893.4 Kb (ftp)(http) TXT
GSE255233_igv_cna_penalty_5.seg.txt.gz 273.1 Kb (ftp)(http) TXT
GSE255233_snv_wgs.vcf.gz 77.5 Mb (ftp)(http) VCF
GSE255233_snv_wxs.vcf.gz 2.0 Mb (ftp)(http) VCF
GSE255233_sv.vcf.gz 3.9 Mb (ftp)(http) VCF
SRA Run SelectorHelp
Raw data are available in SRA

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