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Series GSE254077 Query DataSets for GSE254077
Status Public on May 14, 2024
Title Effect of depletion of NR4A3 on vascular calcification [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Medial arterial calcification is a chronic systemic vascular disorder distinct from atherosclerosis and is commonly observed in patients with chronic kidney disease (CKD), diabetes mellitus, and aging individuals. We previously showed that orphan nuclear receptor NR4A3 is a key regulator in the progression of apolipoprotein (apo) A-IV-induced atherosclerosis; however, little is known about its role in vascular calcification. NR4A3 expression was upregulated in calcified aortic tissues from CKD mice or 1,25(OH)2VitD3 overload-induced mice, and in human calcified aorta. NR4A3 deficiency preserved VSMCs contractile phenotype, inhibited the expression of osteoblast differentiation-related genes, and reduced calcium deposition in the vasculature.
 
Overall design Comparative gene expression profiling analysis of RNA-seq data for WT VSMC and NR4A3 VSMC
 
Contributor(s) Ma W, Jia K, Cheng H, Yan X
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Submission date Jan 24, 2024
Last update date May 14, 2024
Contact name Wenqi Ma
E-mail(s) wenqiM@hotmail.com
Phone +8615905172287
Organization name Shanghai Jiaotong University
Street address 227 Chongqing South Road, Huangpu District, Shanghai, China
City Shanghai
State/province Shanghai
ZIP/Postal code 20025
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (12)
GSM8033088 VSMC, WT, Day14,rep1
GSM8033089 VSMC, WT, Day14,rep2
GSM8033090 VSMC, WT, Day14,rep3
This SubSeries is part of SuperSeries:
GSE254078 NR4A3耗尽对血管钙化的影响
Relations
BioProject PRJNA1068785

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE254077_raw_counts_day1.csv.gz 321.3 Kb (ftp)(http) CSV
GSE254077_raw_counts_day14.csv.gz 328.1 Kb (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA

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