GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE254076 Query DataSets for GSE254076
Status Public on May 14, 2024
Title Effect of depletion of NR4A3 on vascular calcification [CUT&Tag_NR4A3]
Organism Mus musculus
Experiment type Other
Summary Medial arterial calcification is a chronic systemic vascular disorder distinct from atherosclerosis and is commonly observed in patients with chronic kidney disease (CKD), diabetes mellitus, and aging individuals. We previously showed that orphan nuclear receptor NR4A3 is a key regulator in the progression of apolipoprotein (apo) A-IV-induced atherosclerosis; however, little is known about its role in vascular calcification. NR4A3 expression was upregulated in calcified aortic tissues from CKD mice or 1,25(OH)2VitD3 overload-induced mice, and in human calcified aorta. NR4A3 deficiency preserved VSMCs contractile phenotype, inhibited the expression of osteoblast differentiation-related genes, and reduced calcium deposition in the vasculature.
Overall design Comparative gene expression profiling analysis of RNA-seq data for WT VSMC and NR4A3 VSMC
Contributor(s) Ma W, Jia K, Cheng H, Yan X
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jan 24, 2024
Last update date May 15, 2024
Contact name Wenqi Ma
Phone +8615905172287
Organization name Shanghai Jiaotong University
Street address 227 Chongqing South Road, Huangpu District, Shanghai, China
City Shanghai
State/province Shanghai
ZIP/Postal code 20025
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM8033084 VSMC, WT, NR4A3 Input
GSM8033085 VSMC, WT, NR4A3 CUT&Tag, REP1
GSM8033086 VSMC, WT, NR4A3 CUT&Tag, REP2
This SubSeries is part of SuperSeries:
GSE254078 NR4A3耗尽对血管钙化的影响
BioProject PRJNA1068786

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE254076_RAW.tar 312.6 Mb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap