|
| Status |
Public on Aug 09, 2024 |
| Title |
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
This SuperSeries is composed of the SubSeries listed below.
|
| |
|
| Overall design |
Refer to individual Series
|
| |
|
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 19, 2024 |
| Last update date |
Aug 23, 2024 |
| Contact name |
BiNGS Core |
| E-mail(s) |
bings.analytics@gmail.com
|
| Organization name |
Icahn School of Medicine at Mount Sinai
|
| Street address |
1470 Madison Ave
|
| City |
New York |
| ZIP/Postal code |
10029 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (40)
|
| GSM8020596 |
R+Ctrl2 |
| GSM8020597 |
R+Ctrl3 |
| GSM8020598 |
R+SA1 |
| GSM8020599 |
R+SA2 |
| GSM8020600 |
R+SA3 |
| GSM8020601 |
SA+Ctrl1 |
| GSM8020602 |
SA+Ctrl2 |
| GSM8020603 |
SA+Ctrl3 |
| GSM8020604 |
SA+R1 |
| GSM8020605 |
SA+R2 |
| GSM8020606 |
SA+R3 |
| GSM8020607 |
CMP_rep1 |
| GSM8020608 |
CMP_rep2 |
| GSM8020609 |
CMP_rep3 |
| GSM8020610 |
GMP_rep1 |
| GSM8020611 |
GMP_rep2 |
| GSM8020612 |
GMP_rep3 |
| GSM8026614 |
iPSC-derived CD34+/CD45+ sorted cells transduced with NRASG12D lentiviral vector rep1 |
| GSM8026615 |
iPSC-derived CD34+/CD45+ sorted cells transduced with NRASG12D lentiviral vector rep2 |
| GSM8026616 |
iPSC-derived CD34+/CD45+ sorted cells transduced with NRASG12D lentiviral vector rep3 |
| GSM8026617 |
iPSC-derived CD34+/CD45+ sorted cells transduced with NRASG12D followed by SRSF2 P95L & ASXL1del lentiviral vectors rep1 |
| GSM8026618 |
iPSC-derived CD34+/CD45+ sorted cells transduced with NRASG12D followed by SRSF2 P95L & ASXL1del lentiviral vectors rep2 |
| GSM8026619 |
iPSC-derived CD34+/CD45+ sorted cells transduced with NRASG12D followed by SRSF2 P95L & ASXL1del lentiviral vectors rep3 |
| GSM8026620 |
iPSC-derived CD34+/CD45+ sorted cells transduced with SRSF2 P95L & ASXL1del lentiviral vectors rep1 |
| GSM8026621 |
iPSC-derived CD34+/CD45+ sorted cells transduced with SRSF2 P95L & ASXL1del lentiviral vectors rep2 |
| GSM8026622 |
iPSC-derived CD34+/CD45+ sorted cells transduced with SRSF2 P95L & ASXL1del lentiviral vectors rep3 |
| GSM8026623 |
iPSC-derived CD34+/CD45+ sorted cells transduced with SRSF2 P95L & ASXL1del followed by NRAS G12D lentiviral vector rep1 |
| GSM8026624 |
iPSC-derived CD34+/CD45+ sorted cells transduced with SRSF2 P95L & ASXL1del followed by NRAS G12D lentiviral vector rep2 |
| GSM8026625 |
iPSC-derived CD34+/CD45+ sorted cells transduced with SRSF2 P95L & ASXL1del followed by NRAS G12D lentiviral vector rep3 |
| GSM8026725 |
EIPA06_mCherry_GFP_0_G_S1 |
| GSM8026726 |
EIPA06_R_0_G_S1 |
| GSM8026727 |
EIPA06_R_SA_0_G_S1 |
| GSM8026728 |
EIPA06_SA_noR_0_G_S1 |
| GSM8026729 |
EIPA06_SA_R_0_G_S1 |
| GSM8026730 |
EIPA06_SAR_0_G_S1 |
| GSM8042969 |
EIPA06_P6CMP_0_G |
| GSM8042970 |
EIPA06_P7GMP_0_G |
|
| This SuperSeries is composed of the following SubSeries:
|
| GSE235206 |
RAS-mutant AML stem cells acquire resistance to BH3 mimetics through altered BCL-2 family expression |
| GSE253426 |
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics [RNA-Seq] |
| GSE253696 |
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics [ATAC-Seq] |
| GSE253702 |
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics [scRNA-Seq] |
| GSE254478 |
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics [CMPs and GMPs scRNA-Seq] |
|
| Relations |
| BioProject |
PRJNA1066799 |
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